EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Investigation of the sequence of colonization and candidemia in nonneutropenic patients


, : Investigation of the sequence of colonization and candidemia in nonneutropenic patients. Journal of Clinical Microbiology 32(4): 975-980

Among neutropenic patients with hematologic malignancies, candidemia has been shown to arise typically from autoinfection after colonization. In patients without neutropenia, we examined the similarities of strains colonizing or infecting various body sites and those subsequently causing Candida bloodstream infections. Strain similarity was examined by karyotyping and restriction endonuclease analysis of genomic DNA (REAG) by using two restriction enzymes (SfiI and BssHII). The banding patterns of 42 isolates from 19 patients were independently evaluated in a blinded fashion by three observers. The interobserver reliability measured with a generalized kappa statistic was 0.59 for karyotyping, 0.84 for REAG with SfiI, and 0.88 for REAG with BssHII (P < 0.001 for each). REAG classified the initial colonizing or infecting isolate and subsequent blood isolates as identical in 16 patients (84%). The mean duration of colonization or infection prior to a positive blood culture was 5 and 23 days in patients infected with related and unrelated isolates, respectively (P = 0.14; 95% confidence interval = -14.5 to 50.5). Karyotyping results matched the REAG results for isolates from 14 of the 19 patients (74%). In patients infected with identical isolates, the initial isolate was most frequently recovered from the urine (n = 5) or vascular catheter tips (n = 4). In the five subjects with organisms showing disparate results between the methods, karyotyping revealed different banding patterns, whereas REAG suggested that the isolates were identical. Candida colonization or infection with an identical strain frequently precedes bloodstream infection in nonneutropenic patients. Future studies should evaluate whether patients at high risk for candidemia and who have vascular catheter or urine samples that are positive for a Candida on culture should be treated empirically.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 002416952

PMID: 8027353

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Voznesenskii, Vl; Akhmedov, Aa, 1981: Dependence of the phototsynthetic rate of desert plants on oxygen concentration. Problems of desert development = Problemy osvoeniya pustyn: ub 1981) (1) 35-41

Carmichael, L.E.; Joubert, J.C.; Pollock, R.V., 1983: A modified live canine parvovirus vaccine. II. Immune response. An attenuated vaccine induced haemagglutination inhibition antibody titres as early as two days after vaccination. Maximum titres occurred within one week and immunity, which was associated with HI titres of >80, persisted for 2 years. Immunize...

Bewley J.D.; Halmer P., 1981: Embryo endosperm interactions in the hydrolysis of lettuce lactuca sativa cultivar grand rapids seed reserves. Red light- and GA-induced seeds of lettuce (L. sativa L., cv. Grand Rapids) produced copious amounts of endo-.beta.-mannanase after germination was completed. This enzyme was produced and secreted by the endosperm itself and participated in the hy...

Anjali Dhingra; Misra, D. C., 2001: Rural informatics network for e-governance in rural development sector. This paper offers a view of information technology (IT) solutions collaboratively designed and developed by the National Informatics Centre in India for e-governance in the rural development sector. Sections discuss: application software packages;...

Pasquinelli, P.; Vaglini, F.; Pieracci, D.; Ettorre, V.; Puccini, M.; Malvaldi, G., 1989: Effects of thiobenzamide on the rat immune system. Thiobenzamide (TB) is a thiono-containing compound endowed with liver-damaging properties and promoting ability on liver carcinogenesis. When administered in a single dose to normal as well as to adrenalectomized rats, this compound induced a stri...

Bormann, F. H.; Smith, K. R.; Bormann, B. T., 1991: Earth to hearth: a microcomputer model for comparing biofuel systems. To illustrate the problems and potentials of a systems approach to compare alternative biofuel systems in developing countries, we developed a microcomputer model for use with standard spreadsheet software. The model follows several parameters, in...

Braune, W., 1963: The possibility of influencing the action of fungicidal quinones inhibiting germination of fungus spores by means of salts of heavy metals and potassium permanganate. The toxic effects of combinations of sols, of Cu, Cd, Pb, Zn, and Mn-II-salts with p-benzoquinone, tetrachloro-p-benzoquinone, and 2, 3-dichloro-1, 4-naphthoquinone on conidia of Fusarium decemcellulare : 42: 742] were increased or diminished to v...

Bassil, S.; Da Costa, S.; Toussaint-Demylle, D.; Lambert, M.; Gordts, S.; Donnez, J., 1996: A unilateral hydrothorax as the only manifestation of ovarian hyperstimulation syndrome: a case report. Objective: To describe a rare case of unilateral hydrothorax occurrence after ovarian stimulation for IVF. Design: Case report. Setting: A university hospital. Patient(s): A 39-year-old female suffering from primary infertility due to a severe mal...

Patel, Nilay S; Blick, Christopher; Kumar, Sunil; Malone, Peter R, 2008: Luts assessment clinics - A window of opportunity for screening in the aging male. The Journal of Urology 179(4): 577

Idicula-Thomas, S.; Balaji, P.V., 2005: Understanding the relationship between the primary structure of proteins and its propensity to be soluble on overexpression in Escherichia coli. Solubility of proteins on overexpression in Escherichia coli is a manifestation of the net effect of several sequence-dependent and sequence-independent factors. This study aims to delineate the relationship between the primary structure and solub...