Levels of fluconazole in serum, stratum corneum, epidermis-dermis (without stratum corneum) and eccrine sweat

Faergemann, J.; Laufen, H.

Clinical and Experimental Dermatology 18(2): 102-106

1993


ISSN/ISBN: 0307-6938
PMID: 8481982
DOI: 10.1111/j.1365-2230.1993.tb00987.x
Accession: 002423146

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Abstract
The distribution of fluconazole in stratum corneum, epidermis-dermis (without stratum corneum), eccrine sweat and serum was studied in 12 healthy men (aged 22-49 yr), after doses of 50 mg/d for 12 d and 150 mg/wk for 2 wk. High levels of fluconazole were found in the stratum corneum. At 50 mg/d, fluconazole concn after 12 d was 73 micro g/g and 5.8 micro g/g 7 d after cessation of treatment. At 150 mg/wk, the concn 7 d after the second dose was 7.1 micro g/g in the stratum corneum, indicating that medication once weekly may be effective in the treatment of dermatomycoses. Higher concn were found in sweat and epidermis-dermis. It is suggested that fluconazole is delivered to the stratum corneum where it is accumulated, through sweat and direct diffusion through the epidermis-dermis, and should therefore be effective in the treatment of dermatomycoses.

Levels of fluconazole in serum, stratum corneum, epidermis-dermis (without stratum corneum) and eccrine sweat