Levels of terbinafine in plasma, stratum corneum, dermis-epidermis (without stratum corneum) , sebum, hair and nails during and after 250 mg terbinafine orally once daily for 7 and 14 days

Faergemann, J.; Zehender, H.; Millerioux, L.

Clinical and Experimental Dermatology 19(2): 121-126

1994


ISSN/ISBN: 0307-6938
PMID: 8050139
DOI: 10.1111/j.1365-2230.1994.tb01138.x
Accession: 002423170

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Abstract
The skin pharmacokinetic profile of terbinafine (Lamisil) was studied in 2 groups of 8 male volunteers during and after the oral administration of 250 mg/d for 7 and 14 d. After 7 d high terbinafine levels were found in sebum (19.0 micro g/g) and stratum corneum (2.5 micro g/g), and a concn in stratum corneum above the min. inhibitory concn for most dermatophytes was present 48 d after the last day of medication. Terbinafine was found in peripheral nail clippings after 7 d of medication and the concn was 0.5 micro g/g 1 d after stopping medication; the concn was still 0.2 micro g/g 90 d after stopping treatment. Results after 14 d were in parallel with, but higher than, the 7-d study. Elimination of terbinafine from several compartments was biphasic, with a faster initial elimination followed by a slower secondary elimination. For nails, the elimination was slower compared with the other compartments. It is concluded that terbinafine may be effective in short-term treatment of several dermatomycoses. The concn of 0.2 micro g/g of terbinafine found in nails 90 d after stopping medication, following 7 d of treatment, indicates that the duration of therapy, even in tinea unguium, may be shorter than that currently used.

Levels of terbinafine in plasma, stratum corneum, dermis-epidermis (without stratum corneum), sebum, hair and nails during and after 250 mg terbinafine orally once daily for 7 and 14 days