Levels of terbinafine in plasma, stratum corneum, dermis-epidermis (without stratum corneum) , sebum, hair and nails during and after 250 mg terbinafine orally once per day for four weeks

Faergemann, J.; Zehender, H.; Denouël, J.; Millerioux, L.

Acta Dermato-Venereologica 73(4): 305-309

1993


ISSN/ISBN: 0001-5555
PMID: 7904107
Accession: 002423171

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Abstract
The distribution of terbinafine (Lamisil) in stratum corneum, dermis-epidermis (without stratum corneum), serum, hair, nails and plasma was studied in 20 healthy male volunteers (aged 22-49 yr) during and after 250 mg/d orally for 28 d. The highest concn was found in sebum, 56.07 micro g/g, after 14 d of therapy. The concn was 1.0 micro g/g 44 d after medication was stopped. In stratum corneum, the highest concn, 14.4 micro g/g was seen 1 d after the last day of therapy, and 44 d after therapy the concn was 2.1 micro g/g. Concn in hair and nails were lower with a max. of 2.36 and 0.39 micro g/g, respectively, 1 d after the end of therapy, and were 0.21 (hair) and 0.09 micro g/g (nails) 54 d later. Except for nails, all other tissue levels were at all times above the plasma concn. In nails, tissue levels exceeded that of plasma 1 d after the end of medication, and this difference continued to increase until the last day of tissue sampling (55 d after the last treatment). It is concluded that terbinafine is delivered to the stratum corneum through sebum and, to a minor extent, by direct diffusion through dermis-epidermis. It is suggested that short-term therapy with terbinafine may be effective in the treatment of dermatomycoses, due to the strong binding of terbinafine to stratum corneum for a long time after the end of medication.