EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie



PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie



Journal of General Virology 75(5): 989-995



Man and sheep are the two species in which spongiform encephalopathies occur naturally, and in which there are recognized genetic components that predispose an individual person or sheep to clinical disease. In both species mutations/polymorphisms in the PrP gene have been linked to the incidence of natural disease, but only in sheep is it possible to investigate by deliberate exposure to infection whether these polymorphisms are directly correlated with survival time. Cheviot sheep of different PrP genotypes were challenged with one of two isolates of scrapie or an isolate of bovine spongiform encephalopathy and the survival time and incidence of disease were monitored. Genotype analysis showed that dimorphisms in codons 136 and 171 of the ovine Prp gene correlated with control of disease incidence and modulation of incubation time. Crucially, the functional effects of these domains of PrP were shown to alternate depending on the isolate of infecting agent.

(PDF emailed within 0-6 h: $19.90)

Accession: 002463275

Download citation: RISBibTeXText

PMID: 7909834

DOI: 10.1099/0022-1317-75-5-989



Related references

Host genotype and agent effects in scrapie incubation change in allelic interaction with different strains of agent. Molecular and General Genetics 112(1): 73-79, 1971

Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie. Journal of Comparative Pathology 126(1): 17-29, 2002

Isolation of scrapie agent from the placenta of sheep with natural scrapie in Japan. Microbiology and Immunology 37(4): 311-316, 1993

The nature of the scrapie agent. Biological characteristics of scrapie in different scrapie strain-host combinations. Annals of the New York Academy of Sciences 724: 221-234, 1994

Competition between different strains of scrapie agent and their interaction with the host genotype. Heredity 27(2): 313-314, 1971

Scrapie Replication of scrapie agent and the formation of scrapie associated fibril protein in the course of scrapie infection. 1988

Swaledale sheep affected by natural scrapie differ significantly in PrP genotype frequencies from healthy sheep and those selected for reduced incidence of scrapie. Journal of General Virology 74: 1025-1031, 1993

The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks. Proceedings. Biological Sciences 267(1457): 2029-2035, 2001

An experimental examination of the scrapie agent in cell membrane mixtures. I. Stability and physicochemical properties of the scrapie agent. Journal of Comparative Pathology 81(1): 23-32, 1971

Failure to detect abnormal prion protein and scrapie-associated fibrils 6 wk after intracerebral inoculation of genetically susceptible sheep with scrapie agent. Canadian Journal of Veterinary Research 66(4): 289-294, 2002

Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep. Neuroscience Letters 284(3): 175-178, 2000

Failure to detect abnormal prion protein and scrapie-associated fibrils 6 weeks after intracerebral inoculation of genetically susceptible sheep with scrapie agent. Canadian Journal of Veterinary Research 66(4): 289-294, 2002