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Recent experiments with MHC knock-out mice: more questions than answers



Recent experiments with MHC knock-out mice: more questions than answers



Bioessays 15(9): 613-615



Work on mice in which MHC genes have been disrupted by gene targeting of embryonic stem cells, and on mice transgenic for T-cell receptors, is reviewed. The analysis of MHC-deficient mice to date has confirmed the critical role of MHC class I and class II molecules in T-cell development and immune recognition. To a large extent, the elimination of MHC molecules produced the expected deficiencies in the immune system.

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Accession: 002474809

Download citation: RISBibTeXText

PMID: 8240314

DOI: 10.1002/bies.950150907



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