+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Recognition of cellular receptors by bovine coronavirus

Recognition of cellular receptors by bovine coronavirus

Archives of Virology. Supplementum 9: 451-459

Bovine coronavirus (BCV) initiates infection by attachment to cell surface receptors the crucial component of which is N-acetyl-9-O-acetylneuraminic acid. Inactivation of receptors by neuraminidase treatment and restoration of receptors by enzymatic resialylation of asialo-cells is described as a method to determine (i) the type of sialic acid that is recognized; (ii) the linkage specificity of the viral binding activity; (iii) the minimal amount of sialic acid required for virus attachment. Evidence is presented that both glycoproteins and glycolipids can serve as receptors for BCV provided they contain 9-O-acetylated sialic acid. A model is introduced proposing that after initial binding to sialic acid-containing receptors, the S-protein of BCV interacts with a specific protein receptor. This interaction may result in a conformational change that exposes a fusogenic domain and thus induces the fusion between the viral and the cellular membrane.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 002475026

Download citation: RISBibTeXText

PMID: 8032275

Related references

Genomic relationship of porcine hemagglutinating encephalomyelitis virus to bovine coronavirus and human coronavirus OC43 as studied by the use of bovine coronavirus S gene-specific probes. Archives of virology40(7): 1215-1223, 1995

Antigenic relationships among proteins of bovine coronavirus, human respiratory coronavirus OC43, and mouse hepatitis coronavirus A59. Journal of Virology 51(2): 384-388, 1984

Multivalent bovine coronavirus vaccine and method of treating bovine coronavirus infection. Official Gazette of the United States Patent & Trademark Office Patents 1223(5), 1999

Recognition of N-acetyl-9-O-acetylneuraminic acid by bovine coronavirus and hemagglutinating encephalomyelitis virus. Advances in Experimental Medicine and Biology 342: 299-304, 1993

Analysis of cellular receptors for human coronavirus OC43. Advances in Experimental Medicine and Biology 380: 371-374, 1995

Effects of bovine coronavirus on cellular immune responses in neonatal calves. FASEB Journal 4(7): A1885, 1990

Incidence of diarrhoea and of rotavirus- and coronavirus-shedding in calves, whose dams had been vaccinated with an experimental oil-adjuvanted vaccine containing bovine rotavirus and bovine coronavirus. Journal of Veterinary Medicine, B Infectious Diseases, Immunology, Food Hygiene, Veterinary Public Health 35(3): 186-196, 1988

Survey of antibodies to bovine herpesviruses 1, 2 and 4, bovine diarrhoea virus, bovine adenoviruses A and B, and bovine rotavirus and coronavirus in cattle of Western Zaire: additional results. Revue d' Elevage et de Medecine Veterinaire des Pays Tropicaux 42(2): 155-161, 1989

Differential reactivity of bovine coronavirus (BCV) and influenza C virus with N-acetyl-9-O-acetylneuraminic acid (Neu5,9Ac2)-containing receptors. Advances in Experimental Medicine and Biology 276: 115-119, 1990

Oligonucleotide fingerprints of antigenically related bovine coronavirus and human coronavirus OC43. Archives of Virology 86(1-2): 101-108, 1985

Quaternary structure of coronavirus spikes in complex with carcinoembryonic antigen-related cell adhesion molecule cellular receptors. Journal of Biological Chemistry 277(22): 19727-19734, 2002

Experimental inoculation of adult dairy cows with bovine coronavirus and detection of coronavirus in feces by RT-PCR. Archives of Virology 144(1): 167-175, 1999