+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of cadmium induced porphyria by ascorbic acid in chick embryos

, : Regulation of cadmium induced porphyria by ascorbic acid in chick embryos. Indian Journal of Medical Research 94: 387-390

Sublethal doses of cadmium chloride (2.5, 5.0 and 10.0 .mu. mole/kg egg weight) were found to significantly alter the first two rate limiting enzymes of heme biosynthesis in chick embryos. .delta.-aminolevulinic acid synthase activity was elevated by 2.05 and 2.11 fold with 5.0 and 10.0 .mu. moles of cadmium treatment respectively. However, this was reduced to 1.25 and 1.3 fold by the simultaneous administration of ascorbic acid. Blood .delta.-aminolevulinic acid dehydratase (ALA-D) activity was decreased by 48.4 and 55.0 percent with 5.0 and 10.0 .mu. moles cadmium treatment respectively; in the presence of ascorbic acid only 18 and 24 percent inhibition of ALA-D activity was observed. Further 1.39 and 2.08 fold accumulation of .delta.-aminolevulinic acid and 4.17 and 4.62 fold increase of blood porphyrins was observed in chick embryos treated with 5.0 and 10.0 .mu. moles cadmium respectively. This elevation of intermediate compounds of heme biosynthesis was effectively checked by the administration of ascorbic acid. Depletion of hepatic heme and free sulfhydryl level by cadmium were countered by the treatment of ascorbic acid. Hence, the present findings suggest the protective role of ascorbic acid against cadmium induced chemical porphyria in chick embryos.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 002477024

PMID: 1794897

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Czajkowski, G.; Kałuzny, J.; Jatczak-Gaca, A.; Wysocki, M., 2010: Neurofibromatosis type 1--own experiences. Klinika Oczna 112(1-3): 45-48

Henderson A.H., 1990: Edrf and myocardial protection. Journal of Molecular & Cellular Cardiology 22(SUPPL 3): S131-S132

Ziccardi R.J., 1986: Mechanisms of complement activation and control. Journal of Cellular Biochemistry Supplement (10 PART A): 244

Alibrandi, G.; Coppolino, S.; D'Aliberti, S.; Ficarra, P.; Micali, N.; Villari, A., 2003: Variable-ionic strength kinetic experiments in drug stability studies. The dependence of the pseudo-first-order rate constant on the ionic strength for the alkaline hydrolysis of indomethacin has been obtained, for the first time, in a single kinetic experiment carried out by varying with time the salt concentration...

Ha, N.B.; Ku, K.; Ha, N.B.; Chaung, K.T.; Trinh, H.N.; Nguyen, M.H., 2016: Renal Function in Chronic Hepatitis B Patients Treated With Tenofovir Disoproxil Fumarate or Entecavir Monotherapy: A Matched Case-Cohort Study. Journal of Clinical Gastroenterology 49(10): 873-877

Renaud, S.; Gueguen, R., 1999: The French paradox and wine drinking. Despite a high level of risk factors such as cholesterol, diabetes, hypertension and a high intake of saturated fat, French males display the lowest mortality rate from ischaemic heart disease and cardiovascular diseases in Western industrialized...

Zhang, X. D.; Wang, W. L., 1997: Change from promotion to inhibition on apoptosis in hepatoma cells transferred wild-type p53 gene. FASEB Journal 11(9): A1115

Ke, J.; Choi, J.K.; Smith, M.; Horner, H.T.; Nikolau, B.J.; Wurtele, E.S., 1997: Structure of the CAC1 gene and in situ characterization of its expression. The Arabidopsis thaliana gene coding for the biotin-containing subunit of the plastidic acetyl-coenzyme A carboxylase. The CAC1 gene of Arabidopsis thaliana that codes for the biotin carboxyl-carrier subunit of the heteromeric acetyl-coenzyme A carboxylase was isolated and sequenced. CAC1 is a single-copy gene interrupted by six introns. Subcellular immunogold lab...

Crandall, M.A.; Brock, T.D., 1968: Molecular basis of mating in the yeast hansenula wingei. Bacteriological Reviews 32(3): 139-163

Shreeves, WG., 1978: Glanville fritillaries on the Isle of Wight. News British Butterfly Conservation Society, 13-14 No. 21