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Regulation of eukaryotic gene expression by natural antisense transcripts. The case of the modifying reaction


, : Regulation of eukaryotic gene expression by natural antisense transcripts. The case of the modifying reaction. Gene regulation: biology of antisense RNA and DNA: 1-10

The presence of natural antisense transcripts in prokaryotes has been demonstrated for several genes. However, the situation is not as clear in eukaryotes. In no case so far described has it been proved conclusively that an endogenous antisense transcript regulates the production of a particular protein.

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Knee, R.; Murphy, P.R., 1997: Regulation of gene expression by natural antisense RNA transcripts. The use of synthetic antisense oligonucleotides as specific inhibitors of gene expression exploits the susceptibility of mRNA to functional blockade at several levels, including mRNA processing, transport, translation and degradation. It is becomi...

Knee, R.; Murphy, P.R., 1997: Regulation of gene expression by natural antisense RNA transcripts. The use or synthetic antisense oligonucleotides as specific inhibitors of gene expression exploits the susceptibility of mRNA to functional blockade at several levels, including mRNA processing, transport, translation and degradation. It is becomi...

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