+ Translate

Regulation of food intake and body weight in rats by the synthetic heme analogue cobalt protoporphyrin

, : Regulation of food intake and body weight in rats by the synthetic heme analogue cobalt protoporphyrin. American Journal of Physiology 261(6 Pt 2): R1388-R1394

Cobalt protoporphyrin (CoPP) in single subcutaneous doses produces prolonged weight loss in adult and aged male rats. The altered body weight level in treated animals is actively defended against starvation or overfeeding over prolonged time periods (greater than 50-100 days). The actions of CoPP on appetite and body weight regulation are biphasic, comprising an initial period of hypophagia, probably mediated centrally, until a particular body weight level is attained. Resumption of normal calorie intake follows, although lowered body weight levels are sustained, suggesting an additional action of the compound on peripheral substrate metabolism. Controlled decrements in body weight can be produced by repetitive low-dose CoPP treatment (e.g., 1 mumol/kg body wt weekly); low-dose regimens do not elicit altered hormonal homeostasis or aberrations in heme/cytochrome P-450 regulation that have been observed following larger doses (25-50 mumol/kg body wt) of the compound. CoPP may be a valuable probe with which to explore the role of heme-related molecules in the regulation of appetite and body weight.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 002477100

PMID: 1750563

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Lee, C-Hyeong.; Loureiro-Silva, M.R.; Abraldes, J.G.; Iwakiri, Y.; Haq, O.; Groszmann, R.J., 2007: Decreased intrahepatic response to alpha(1)-adrenergic agonists in lipopolysaccharide-treated rats is located in the sinusoidal area and depends on Kupffer cell function. Background and aim: Livers from lipopolysaccharide-treated rats have a decreased vascular response to alpha(1)-adrenergic agonists due to an increased production of nitric oxide. Kupffer cells play a central role in the development of intrahepati...

Navarrete-Heredia, Jl; Cortes-Aguilar, J., 2006: Abundance and distribution of two Nicrophorus species from Baja California, Mexico (Coleoptera: Silphidae). A survey in northern Baja California, Mexico was done to collect carrion beetles in June 2005. Two silphid species were collected: Nicrophorus guttula Motschulsky, 1845 and, N. nigrita Mannerheim, 1843. In this paper we provide information about t...

Notario A.; Azzara A.; Petrucci E.; Invernizzi R.; Luraschi A., 1982: Prostaglandin e 1 and prostaglandin e 2 patterns in normal and leukemic granulocytes during in vitro phagocytosis. The behavior of phagocytosis and that of PG[prostaglandin]E1 and PGE2 in the circulating granulocytes of normal and leukemic subjects was investigated by the comparison of latex particles and the PAP (peroxidase-antiperoxidase) immuno-enzymatic me...

Mandel, Jean Louis, 1996: Monogenic neurological disorders Progress and prospects. M-S (Medecine Sciences) 12(SPEC ISSUE): 100-108

Li, J. Y.; Zhang, S. C., 1990: Effects of pre-inoculation of non-pathogenic Fusarium oxysporum on the growth of Fusarium wilt on watermelon. Of 203 strains of F. oxysporum collected from northern China, 109 were selected as non-pathogenic. Ten of these strains which stimulated growth of watermelon were inoculated to soil before planting of watermelon seeds in greenhouse and field trial...

Hall J.S.; Keeton T.K., 1981: The metabolism of propranolol in the spontaneously hypertensive rat. Federation Proceedings 40(3 PART 1): 649

Schoenfeld J.; Ruenzi M.; Mueller M.K., 1992: Effect of cysteamine on endocrine and exocrine pancreatic secretion in vitro. Gastroenterology 102(4 PART 2): A297

Saka, Hitoshi, 1994: Perspective of low temperature science in Hokkaido agriculture. Saka, H [Editor] Low temperature physiology and breeding of northern crops 9-13

Williams, A. M.; Williams, R. R., 1978: Regulation of movement of assimilate into ovules of Pisum sativum cv. Greenfeast: a 'remote' effect of the pod. Labelled CO2 was fed to the single leaf of pea plants pruned to leave one leaf and one pod. Localized heating of the pod, removal of ovules and determination of 14C activity in soluble sugars and starch fractions were used to investigate the enhan...

Stanyon, R., 2000: In situ hybridization, chromosome evolution and phylogeny in primates. Folia Primatologica 71(4): 268-269, July-August