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Regulation of gene expression during squamous differentiation by multiple retinoic acid signalling pathways

, : Regulation of gene expression during squamous differentiation by multiple retinoic acid signalling pathways. Retinoids: from basic science to clinical applications: 243-252

Evidence that the regulation of squamous differentiation is complex, differs among tissues, and involves a multiplicity of signalling pathways, is reviewed. Vitamin A deficiency induces squamous differentiation in several epithelia including tracheobronchial and uterine epithelia. Retinoids suppress expression in vitro of many squamous cell-specific genes, including involucrin, transglutaminase type 1, cornifin, cholesterol sulfotransferase, loricrin and several keratins.

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