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Regulation of immunity to Ostertagia ostertagi


, : Regulation of immunity to Ostertagia ostertagi. Veterinary Parasitology 46(1-4): 63-79

Knowledge of bovine immune response to ostertagiasis is important to understanding the mechanisms of innate and acquired immunity to this economically important helminth parasite that infects cattle worldwide. Infection causes both antibody and cellular immune responses. Evidence shows that Ostertagia possesses excretory-secretory (ES) molecules that may regulate immune cell responses that affect acquired immunity and pathophysiological changes to infection. Ostertagia can down-regulate antibody and cellular immune responses. One of these ES regulatory molecules is a lectin that causes eosinophil chemotaxis. In addition to its antigenicity, this regulatory molecule serves as a means of communication between the parasite and cells of the host immune system. It is suggested that, lacking this type of communication, Ostertagia infection may not be readily recognized by the host immune cells. A hypothesis is proposed for the mechanisms of acquired immunity to Type I ostertagiasis. Regulatory molecules of Ostertagia ES are suggested as suitable vaccine candidates.

Accession: 002477152

PMID: 8484225

DOI: 10.1016/0304-4017(93)90048-r

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Related references

Klesius, P.H., 1993: Regulation of immunity to Ostertagia ostertagi. Knowledge of bovine immune response to ostertagiasis is important to understanding the mechanisms of innate and acquired immunity to this economically important helminth parasite that infects cattle worldwide. Infection causes both antibody and ce...

Michel, J.F.; Lancaster, M.B.; Hong, C., 1973: Ostertagia ostertagi: protective immunity in calves. The development in calves of a protective immunity to infection with ostertagia ostertagi. Resistance to the establishment of O. ostertagi was tested in calves which had been infected daily with 1000 larvae for 30, 80, 150 and 250 days. The proportion of a challenge dose of 30000 larvae which became established decreased steadily and by...

Michel, J.; Lancaster, M.; Hong, C., 1973: Ostertagia ostertagi: Protective immunity in calves; the development in calves of protective immunity to infection with Ostertagia ostertagi. Experimental parasitology: 33 (1) 179-186

Michel, J.F.; Lancaster, M.B.; Hong, C., 1973: Ostertagia ostertagi: protective immunity in calves. The development in calves of a protective immunity to infection with Ostertagia ostertagi. Experimental Parasitology 33(1): 179-186

Snider, T.G.; Williams, J.C.; Karns, P.A.; Trammell, H.E.; Romaire, T.L., 1985: Synergistic influence of Ostertagia ostertagi and Trichostrongylus axei on Ostertagia ostertagi larval inhibition and abomasal lesions in cattle. Parasite-free 4-month-old calves were inoculated with Ostertagia ostertagi and/or Trichostrongylus axei followed 6 weeks later by increasing doses of O ostertagi for 8 weeks. Clinical signs of parasitism, fecal egg counts, and plasma pepsinogen co...

Cross D.A.; Klesius P.H.; Hanrahan L.A.; Haynes T.B., 1987: Dermal cellular responses of helminth free and ostertagia ostertagi infected calves to intradermal injections of soluble extracts from ostertagia ostertagi l 3 larvae. Twelve calves were raised helminth-free until 9 weeks of age when six were orally inoculated with 100,000 Ostertagia ostertagi infective stage larvae (L3). Three uninfected and three experimentally infected calves received intradermal injections o...

Snider, T.G.; Klesius, P.H.; Haynes, T.B., 1985: Dermal responses to Ostertagia ostertagi in Ostertagia ostertagi- and Cooperia punctata-inoculated calves. Calves were orally inoculated with 40 000 L3 of O. ostertagi or C. punctata and 30 days later were inoculated intradermally at a single location with 200 micro g of O. ostertagi L3 crude extract. 30 days later a 2nd series of injections was given....

Klesius, P.H., 1988: Immunity to Ostertagia ostertagi. Control of ostertagiasis is a major economic problem in the temperate areas of the world. An immunological control scheme for cattle is an important aspect of integrated control and its achievement is dependent on our understanding of how immunity...

Klesius, P.H., 1988: Immunity to Ostertagia ostertagi. Control of ostertagiasis is a major economic problem in the temperate areas of the world. An immunological control scheme for cattle is an important aspect of integrated control and its achievement is dependent on our understanding of how immunity...

Snider T.G.IIi; Klesius P.H.; Haynes T.B., 1985: Dermal responses to ostertagia ostertagi in ostertagia ostertagi inoculated and cooperia punctata inoculated calves. American Journal of Veterinary Research 46(4): 887-890