EurekaMag.com logo
+ Translate

Regulation of immunoglobulin gene expression: lessons from transgenic mice


, : Regulation of immunoglobulin gene expression: lessons from transgenic mice. Immunotechnology: Proceedings of the 21st Federation of European Biochemical Societies Meeting, Dublin: 13-26

This review covers the expression of rearranged Ig genes, heavy and light chain enhancers, transgene expression and allelic exclusion, somatic hypermutation of transgenes, rearrangement of Ig transgenes, and applied aspects of Ig transgenes.

(PDF 0-2 workdays service)

Accession: 002477153

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Storb U.; Ritchie K.A.; O'brien R.L.; Arp B.; Brinster R.L., 1985: Regulation of immunoglobulin gene expression in transgenic mice. Streilein, J W Et Al (Ed ) Icsu (International Council Of Scientific Unions) Short Reports, Vol 2 Advances in Gene Technology: Molecular Biology Of The Immune System; 17th Miami Winter Symposium, Miami, Fla , Usa, Feb 11-15, Xxiii+366p Cambridge University Press: New York, N Y , Usa; Cambridge, England Illus 15-18

Spear, B.T., 1999: Alpha-fetoprotein gene regulation: lessons from transgenic mice. The mouse alpha-fetoprotein (AFP) gene provides an excellent model system to study developmental gene activation and different aspects of liver-specific transcriptional control. AFP is activated early in hepatogenesis, repressed post-natally, and...

Weaver D.; Reis M.H.; Albanese C.; Costantini F.; Baltimore D.; Imanishi Kari T., 1986: Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene. C57BL/6 mice transgenic for a .mu. heavy chain gene, the VDJ region of which came from the BALB/c hybridoma 17.2.25, expressed high levels of antibody carrying determinants specific for the transgene (idiotypes). The individual antibodies made by...

Storb, U.; Kindred, A.R.; Hammer, R.E.; O.B.ien, R.L.; Manz, J.T.; Arp, B.; Brinster, R.L., 1985: Expression of a microinjected immunoglobulin kappa gene in transgenic mice. Transgenic mice with a rearranged, functional immunoglobulin kappa gene in their somatic and germ cells were produced. Six transgenic mice and their transgenic offspring had large amounts of the specific kappa chains in their serum. The results in...

Brinster, R.L.; Ritchie, K.A.; Hammer, R.E.; O'Brien, R.L.; Arp, B.; Storb, U., 1983: Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice. Transgenic mice were produced by microinjection of a rearranged, functional immunoglobulin kappa gene into fertilized mouse eggs and implantation of the microinjected embryos into foster mothers. Mice that integrated the injected gene were mated a...

Weaver, D.; Albanese, C.; Costantini, F.; Baltimore, D., 1991: Retraction: altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene. Cell 65(4): 536-536

Eccles, S.; Sarner, N.; Vidal, M.; Cox, A.; Grosveld, F., 1990: Enhancer sequences located 3' of the mouse immunoglobulin lambda locus specify high-level expression of an immunoglobulin lambda gene in B cells of transgenic mice. In contrast to the mouse immunoglobulin heavy chain and kappa light chain genes, very little is known about the regulation of expression of the immunoglobulin lambda light chain locus. To identify elements responsible for lambda gene regulation we...

Eccles S.; Sarner N.; Vidal M.; Cox A.; Grosveld F., 1991: Enhancer sequences located 3 of the mouse immunoglobulin lambda locus specific high level expression of an immunoglobulin lambda gene in b cells of transgenic mice. Journal of Cellular Biochemistry Supplement (15 PART A): 186

O'connell, C.; Longo, D.; Hill, S.; Hurst, J.; Kenny, J., 1993: Endogenous immunoglobulin gene expression during fetal development of IgA transgenic mice. Journal of Cellular Biochemistry Supplement 0(17 PART B): 233

Huszar, D.; Hollenbach, P.; Munoz O'regan, D.; Choi, T.; Carmack, C.E., 1994: Expression of human heavy chain immunoglobulin gene YACs in transgenic mice. Journal of Cellular Biochemistry Supplement 0(18D): 201