EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of intestinal nutrient transport is impaired in aged mice


Journal of Nutrition 123(3): 502-511
Regulation of intestinal nutrient transport is impaired in aged mice
To determine the effect of age on the regulation of intestinal nutrient absorption, we fed young (7.6-mo-old) and aged (24.8-mo-old) C57BL mice diets designed to stimulate in vitro sugar or amino acid uptake in the isolated small intestine. In each age group, diet had no effect on feeding rates and body weights. D-Glucose and D-fructose uptakes by the small intestine each increased by about two times in young and 1.5 times in aged mice fed high carbohydrate diets as compared with those fed no carbohydrate. Adaptive increases in uptake by the aged group were not only reduced but also restricted to more proximal regions of the small intestine. In both age groups, diet-stimulated increases in D-glucose transport were accompanied by parallel increases in number of Na(+)-D-glucose cotransporters as estimated by specific phlorizin binding. Diet had no effect on transporter Kd for phlorizin, turnover rate of each transporter, mucosal mass or mucosal permeability. A high protein diet stimulated the uptake of L-aspartate and L-proline in young mice and of only L-aspartate in aged mice. Uptake of essential amino acids and of nonessential amino acids sharing transporters with essential ones were not regulated. Although aged mice possess adaptive mechanisms to diet that are similar to those in young mice, the effectiveness of these mechanisms may be impaired with age and may result in malabsorption symptoms so prevalent in the elderly.


Accession: 002477159

PMID: 8463853



Related references

Impaired placental nutrient transport in mice generated by in vitro fertilization. Endocrinology 153(7): 3457-3467, 2012

Regulation of intestinal nutrient transport. Johnson, L R [Editor] Physiology of the gastrointestinal tract, Vols 1 and 2, Third edition 1821-1844, 1994

Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice. Arteriosclerosis, Thrombosis, and Vascular Biology 33(12): 2858-2866, 2014

Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 291(5): R1533-8, 2006

The nutritional significance of regulation of intestinal nutrient transport. Nutritional modulation of neural function edited by John E Morley M Barry Sterman John H Walsh: 3, 1988

Experience-dependent regulation of synaptic zinc is impaired in the cortex of aged mice. Neuroscience 119(3): 795-801, 4 July, 2003

Intestinal nutrient transport in genetically obese mice. American Journal of Clinical Nutrition 62(3): 540-546, 1995

Effects of changes in calorie intake on intestinal nutrient uptake and transporter mRNA levels in aged mice. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 52(6): B300-B310, 1997

Growth factor regulation of enterocyte nutrient transport during intestinal adaptation. American Journal of Surgery 183(4): 361-371, 2002

Nutrient regulation of human intestinal sugar transport (SGLT1) expression. Gut 41(1): 56-59, 1997