EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids


, : Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids. Annual Review of Nutrition 13: 355-381

Extensive data obtained in both experimental animals and humans demonstrate that steady-state plasma LDL-C concentrations are determined largely by the rate of LDL-C formation, Jt, and the level of LDL-R activity, Jm, located primarily in the liver. An increase in net cholesterol delivery to the liver suppresses Jm, slightly elevates Jt, and modestly raises the LDL-C level. Feeding lipids such as the 12:0, 14:0, and 16:0 saturated fatty acids further suppresses Jm, increases Jt, and markedly elevates the plasma LDL-C concentration. Feeding triacylglycerols containing the 18:1(c9) fatty acid restores hepatic receptor activity, decreases Jt, and modestly reduces the concentration of LDL-C in the plasma. The 18:2(c9, c12) compound has similar effects, although it is quantitatively less active than the monounsaturated fatty acid in restoring Jm. In contrast to these fatty acids that actively raise or lower hepatic receptor activity, a large group of compounds including the 4:0, 6:0, 8:0, 10:0, 18:0, and 18:1(t9) fatty acids have no demonstrable effect on any parameter of LDL-C metabolism. These fatty acids, therefore, can be added to animal and human diets with relative impunity. They will alter plasma LDL-C levels only to the extent that they replace the active saturated fatty acids (in which case they lower the LDL-C concentration) or unsaturated compounds (in which case they raise the plasma cholesterol level). All of these effects of cholesterol and the various fatty acids can be explained by the effects of these lipids in altering the size of the regulatory pool of cholesterol in the hepatocyte. However, many aspects of the cellular and molecular biology of these regulatory processes require additional investigation. In particular, new studies should focus on how the genetic background of an individual animal or human alters the quantitative response of its plasma LDL-C concentration to the dietary challenge of each of these types of lipids.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 002477232

PMID: 8369151

DOI: 10.1146/annurev.nu.13.070193.002035

PDF Full Text: Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Walter, Heinrich, 1929: The winter damages to our evergreen plants during the cold period and their causes. The damage by cold is explained through an overstepping of the maximum osmotic value of the protoplasm of the plants. The cold resistance depends on the height of the maximal value of a sp. (Omax), and on the velocity with which the osmotic value...

Hannan, J.H., 1927: On Certain Adrenaline Effects at the Menopause and their Significance. British Medical Journal 2(3469): 14-15

Meng, W.S.oll, H., 1975: First results of the test uses of the RW 30 Timberjack forest thinning harvester. Forsttechnische Informationen: 27 (1) 5-8

Sussman, G.; Cohen, D.M., 1999: Pumping chamber for a liquefaction handpiece having a countersink electrode. A surgical handpiece having at least two lumens mounted to a body. At least one lumen is used for aspiration and at least one other lumen is used to inject heated surgical fluid for liquefying a cataractous lens. A portion of the second lumen is e...

Talaat, M.; Guindy, A.; Ageeb, M.; E.B.goury, I., 1963: Use of adenosine triphosphate in acute ischaemia of limbs. Intraarterial injection of adenosine triphosphate (ATP) delays the onset of fatigue in the gastrocnemius muscle after the ligation of both femoral vessels with or without simultaneous ligation of the abdominal aorta. This effect of ATP is partly d...

Ulber, Bernd., 1992: Vergleichende Untersuchungen zur Flugaktivitat und Abundanz von Ceutorhynchus napi Gyll. und Ceutorhynchus pallidactylus (Mrsh.) in den Jahren 1989-1991. Mitteilungen aus der Biologischen Bundesanstalt fuer Land- und Forstwirtschaft Berlin-Dahlem, 283: 87

Miner, J.H., 1998: Developmental biology of glomerular basement membrane components. The main components of basement membranes are collagen IV, laminin, entactin/nidogen, and proteoglycans. In the past few years, new basement membrane components have been discovered, including new collagen i.v. alpha chains, new laminin alpha, bet...

Fujii, T.; Tsutsumi, S.; Matsumoto, A.; Fukasawa, T.; Tabe, Y.; Yajima, R.; Asao, T.; Kuwano, H., 2010: Thickness of subcutaneous fat as a strong risk factor for wound infections in elective colorectal surgery: impact of prediction using preoperative CT. In this study, we have attempted to identify and assess factors that would be most predictive of postoperative incisional surgical site infection (SSI) in colorectal surgery, including representative markers for nutrition or obesity. 152 patients...

Spero, D., 2003: The healing value of fun. Diabetes Self-Management 19(5): 36-39

Bandara, B.M.; Hewage, C.M.; Karunaratne, V.; Adikaram, N.K., 1988: Methyl ester of para-coumaric acid: antifungal principle of the rhizome of Costus speciosus. Planta Medica 54(5): 477-478