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Regulation of rat ileal water absorption by central alpha 2 adrenergic receptors


Digestive Diseases and Sciences 35(6): 737-742
Regulation of rat ileal water absorption by central alpha 2 adrenergic receptors
This study examined the role of central adrenergic receptors in the regulation of water absorption by the rat ileum. Clonidine, an .alpha.2-adrenergic receptor agonist, increased water absorption in vivo following intracerebroventricular but not intravenous injection. Intracerebroventicular injection of prazosin, an .alpha.1-adrenergic receptor antagonist, did not alter basal water absorption. Prazosin did not prevent the clonidine effect. In contrast, the .alpha.2-adrenergic receptor antagonist, yohimbine, reduced basal absorption and prevented the intracerebroventricular clonidine effect. Treatment with reserpine reduced ileal norepinephrine content by 98%, reduced basal water absorption consistent with a loss of sympathetic outflow to the mucosa, but did not prevent the increase in water absorption due to intracerebroventricular clonidine. These results suggest that central .alpha.2 receptors regulate water absorption by the rat ileum. The clonidine-induced increase in water absorption is not mediated by the sympathetic nerves innervating the intestine.

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Accession: 002477251

PMID: 1971561



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