+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of the anorectic drug recognition site during glucoprivic feeding

, : Regulation of the anorectic drug recognition site during glucoprivic feeding. Brain Research Bulletin 28(2): 201-208

The acute effects of 2-deoxy-D-glucose (2-DG)-induced glucoprivic feeding on the anorectic drug recognition site and Na+K+-ATPase in the brain were examined in adult rats and in lean and genetically obese mice. The marked hyperglycemia and the induction of feeding caused by the administration of 2-DG to satiated rats and lean mice were associated with significant increases in Na+K+-ATPase activity, and in [3H]ouabain binding and [3H]mazindol binding to the anorectic drug recognition site in hypothalamic membranes. Basal and 2-DG-stimulated levels of blood glucose were significantly correlated to the levels of hypothalamic [3H]ouabain (r = + .91, p < 0.01) and [3H]mazindol (r = + .87, p < 0.01) binding. A significant correlation (r = .74, p < 0.05) was also observed [3H]mazindol binding and [3H]ouabain binding supporting the hypothesis that these hypothalamic binding sites are functionally coupled in their response to circulating glucose. Following the intracerebroventricular (ICV) administration of the diabetogenic drug alloxan, 2-DG did not stimulate feeding or increase [3H]mazindol and [3H]ouabain binding sites in the hypothalamic paraventricular area. Since 2-DG still caused hyperglycemia in alloxan-treated rats, alloxan-induced inactivation of glucoreceptor mechanisms led to an uncoupling of the anorectic drug recognition site from a hypothalamic glucostat. In genetically obese mice (ob/ob), 2-DG also could not induce feeding or increase hypothalamic [3H]ouabain or [3H]mazindol binding, despite a significant hyperglycemic response. In contrast, 2-DG did increase feeding and the binding of [3H]ouabain and [3H]mazindol to the hypothalamus of lean littermates. The dissociation of the anorectic drug recognition site from blood glucose responses to 2-DG suggests that the glucoprivic feeding response in obese mice is impaired. In conclusion, the [3H]mazindol recognition site and the neuronal Na+KP+-ATPase KP+-ATPase labelled by [3H]ouabain binding constitutes a glucoreceptive system which is response to changes in circulating glucose levels modulates feeding. Since the coupling of this anorectic drug recognition site to brain glucostats is defective in genetically obese mice, this system may have an important role in pathological hyperphagia and the development of obesity.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 002477282

PMID: 1317740

DOI: 10.1016/0361-9230(92)90180-6

Download PDF Full Text: Regulation of the anorectic drug recognition site during glucoprivic feeding

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Toriumi, D.M.; Wolff, A.P., 1988: Pathologic quiz case 1. Extramedullary plasmacytoma of the right maxillary sinus. Archives of Otolaryngology--Head & Neck Surgery 114(3): 338-340

Nandakumar H.; Shankaramba K.B., 1990: Massive sequestration of the upper jaw a case report. Massive sequestration of the upper jaw has been reported only rarely in the literature. A case is presented of a 65-year-old diabetic male with massive sequestration of the maxilla. The relevant literature is reviewed.

Kovács, G.L.; Telegdy, G., 1976: Inhibitory effect of midbrain raphe stimulation on the maintenance of an active avoidance reflex. Performance of an active avoidance (bench-jumping) reflex has been studied in rats during stimulation of the midbrain raphe nuclei. Raphe stimulation (10 cps, 0.2 msec, 2.5-5.0 V) inhibited the performance of the reflex. A serotonin receptor block...

Santarpia, M.; Altavilla, G.; Pitini, V.; Rosell, R., 2016: Personalized treatment of early-stage non-small-cell lung cancer: the challenging role of EGFR inhibitors. Adjuvant cisplatin-based chemotherapy significantly improves outcomes of completely resected early-stage non-small-cell lung cancer (NSCLC) patients. However, its effect on overall survival is limited and may be unsuitable for many patients due to...

Riera-Leal, L.; Guevara-Gutiérrez, E.; Barrientos-García, J.Gabriel.; Madrigal-Kasem, R.; Briseño-Rodríguez, G.; Tlacuilo-Parra, A., 2016: Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. Porocarcinoma is a rare tumor, representing 0.005% of all malignant epithelial neoplasms. The majority of publications are single case reports. The objective of this study was to describe the epidemiologic and histopathologic characteristics of pa...

Jackson G.D.; Iannelli T.R.; Tilley B.J., 1980: Rift-related late Proterozoic sedimentation and volcanism on northern Baffin and Bylot islands, District of Franklin. Paper - Geological Survey of Canada 80-1A): 319-328

Espinoza, M.A.; Oyarte, M.; Villegas, R.; Balmaceda, C.; Basagoitia, A.; Diaz, J., 2015: Gasto de Bolsillo en Salud y Medicamentos en Chile: Análisis Comparativo de Los Periodos 1997, 2007 y 2012. Value in Health 18(7): A846-A847

Widdows, J.; Donkin, P.; Salkeld, PN.; Evans, SV., 1987: Measurement of scope for growth and tissue hydrocarbon concentrations of mussels (Mytilus edulis) at sites in the vicinity of the Sullom Voe oil terminal:- a case study. Unknown

Reisfield, G.; Paulian, G.; Merlo, L.; Bertholf, R.; Wilson, G., 2010: Opioid prescription underfilling among retail pharmacies. Prescription opioid abuse is a major public health problem in the United States. Physicians who prescribe opioid analgesics are sometimes confronted with patients who request early refills, claiming that they have been "shorted" by their...

Jack, A.; Ladner, J.E.; Klug, A., 1976: Crystallographic refinement of yeast phenylalanine transfer RNA at 2-5A resolution. Journal of Molecular Biology 108(4): 619-649