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Regulation of the anorectic drug recognition site during glucoprivic feeding

, : Regulation of the anorectic drug recognition site during glucoprivic feeding. Brain Research Bulletin 28(2): 201-208

The acute effects of 2-deoxy-D-glucose (2-DG)-induced glucoprivic feeding on the anorectic drug recognition site and Na+K+-ATPase in the brain were examined in adult rats and in lean and genetically obese mice. The marked hyperglycemia and the induction of feeding caused by the administration of 2-DG to satiated rats and lean mice were associated with significant increases in Na+K+-ATPase activity, and in [3H]ouabain binding and [3H]mazindol binding to the anorectic drug recognition site in hypothalamic membranes. Basal and 2-DG-stimulated levels of blood glucose were significantly correlated to the levels of hypothalamic [3H]ouabain (r = + .91, p < 0.01) and [3H]mazindol (r = + .87, p < 0.01) binding. A significant correlation (r = .74, p < 0.05) was also observed [3H]mazindol binding and [3H]ouabain binding supporting the hypothesis that these hypothalamic binding sites are functionally coupled in their response to circulating glucose. Following the intracerebroventricular (ICV) administration of the diabetogenic drug alloxan, 2-DG did not stimulate feeding or increase [3H]mazindol and [3H]ouabain binding sites in the hypothalamic paraventricular area. Since 2-DG still caused hyperglycemia in alloxan-treated rats, alloxan-induced inactivation of glucoreceptor mechanisms led to an uncoupling of the anorectic drug recognition site from a hypothalamic glucostat. In genetically obese mice (ob/ob), 2-DG also could not induce feeding or increase hypothalamic [3H]ouabain or [3H]mazindol binding, despite a significant hyperglycemic response. In contrast, 2-DG did increase feeding and the binding of [3H]ouabain and [3H]mazindol to the hypothalamus of lean littermates. The dissociation of the anorectic drug recognition site from blood glucose responses to 2-DG suggests that the glucoprivic feeding response in obese mice is impaired. In conclusion, the [3H]mazindol recognition site and the neuronal Na+KP+-ATPase KP+-ATPase labelled by [3H]ouabain binding constitutes a glucoreceptive system which is response to changes in circulating glucose levels modulates feeding. Since the coupling of this anorectic drug recognition site to brain glucostats is defective in genetically obese mice, this system may have an important role in pathological hyperphagia and the development of obesity.

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Accession: 002477282

PMID: 1317740

DOI: 10.1016/0361-9230(92)90180-6

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Uno, H.; Ueki, Y.; Murashima, J.; Miyake, S.; Tominaga, Y.; Eguchi, K.; Yano, K., 1995: Removal of LDL from plasma by adsorption reduces adhesion molecules on mononuclear cells in patients with arteriosclerotic obliterance. Background: There is increasing evidence that immune processes are important in the development of atherosclerosis. We investigated whether low density lipoprotein (LDL) adsorption therapy affected serum cytokine levels and the expression of adhes...

Kvasnikov, E.I.; Smirnova, G.F.; Kliushnikova, T.M.; Kuberskaia, S.L., 1987: Effect of environmental factors on the destruction of petroleum products by associative microorganism cultures. Mikrobiologicheskii Zhurnal 49(3): 33-38

Roberts, J., 1983: Playing at work. The report describes the provision of sports facilities by employers and investigates whether the siting of the facilities adjacent to a place of work is convenient to employees, whether the employees are satisfied with the provision, and the cons...

Boone J.B.Jr; Lambert C.P.; Flynn M.G.; Rodriguez Zayas J.A.; Michaud T.J., 1989: The effects of a weight training session on cortisol and creatine kinase activity in steroid and non steroid users. Medicine & Science in Sports & Exercise 21(2 SUPPL): S70

Friis H.M.U., 1988: The use of antibiotics in denmark and its control. Ugeskrift for Laeger 150(32): 1911-1912

Gratton, C.; Lisewski, B., 1980: The economics of sport: a review. The review falls into two distinct categories - the economics of professional team sports and the economics of sport as a leisure activity. The literature on professional team sports focuses on studies undertaken in the UK and N. America. Writers...

Jasko Sandor, 1933: Morfologiai megfigyelesek es problemak a Goemoer-Tornai karsztvidek delkeleti reszeben. Observations on the physiography of the southeastern part of the Goemoer-Tornaer karst region, Hungary.

Fletcher, J. A., 1924: Does Tasmania possess a second species of Blue Wren (Malurus) ?. Emu Melbourne, 23: 206-208

Genov, T.; Murai, E.; Harris, EA.; Georgiev, BB., 1988: Taxonomic remarks on Anoplocephaloides spp. (Cestoda: Anoplocephalidae) parasitizing rabbits. Unknown

STEINBERG.D.; VAUGHAN.M.; NESTEL.P.J.; BERGSTROM.S., 1963: Effects of prostaglandin E opposing those of catecholamines on blood pressure and on triglyceride breakdown in adipose tissue. Biochemical Pharmacology 12: 764-766