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Regulation of zygotic gene activation in the mouse

, : Regulation of zygotic gene activation in the mouse. Bioessays 15(8): 531-538

Zygotic gene activation (ZGA) is the critical event that governs the transition from maternal to embryonic control of development. In the mouse, ZGA occurs during the 2-cell stage and appears to be regulated by the time following fertilization, i.e. a zygotic clock, rather than by progression through the first cell cycle. The onset of ZGA must depend on maternally inherited proteins, and post-translational modification of these maternally derived proteins is likely to play a role in ZGA. Consistent with this prediction is that protein phosphorylation catalyzed by the cAMP-dependent protein kinase is involved in ZGA and that protein synthesis is not required for ZGA. Recent results suggest that ZGA may occur earlier than previously thought, i.e. not during the 2-cell stage, but rather in G2 of the 1-cell embryo. Thus ZGA may comprise a period of minor gene activation in the 1-cell embryo that is followed by a period of major gene activation in the 2-cell embryo. Following ZGA, the expression of constitutively activated genes may require an enhancer.

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Accession: 002477336

PMID: 8135766

DOI: 10.1002/bies.950150806

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Mazière, Cécile.; Salle, Véry.; Gomila, C.; Mazière, J-Claude., 2013: Oxidized low density lipoprotein increases RANKL level in human vascular cells. Involvement of oxidative stress. Receptor Activator of NFκB Ligand (RANKL) and its decoy receptor osteoprotegerin (OPG) have been shown to play a role not only in bone remodeling but also in inflammation, arterial calcification and atherosclerotic plaque rupture. In human smooth...

Campbell, L.C., 1976: You could have been a steam doctor. Journal of the Mississippi State Medical Association 17(10): 298-302

Elsasser, W.M., 1964: Synopsis of organismic theory. The theory developed over a number of years by this author is here surveyed in a concise form, there being a sequence of definitions, assumptions and propositions, with connecting and explanatory text. Organismic theory is not identical with biolo...

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Kovalenko, A.F.; Chulak, L.D.; Zubkova, L.P., 1988: Enzyme therapy of patients with sialosis. Stomatologiia 67(3): 46-48

RALSTON, B., 1951: Erosions and acute perforative lesions of the upper gastrointestinal tract and their relation of central nervous system lesions. A.M.A. Archives of Neurology and Psychiatry 66(5): 662-663

Aderibigbe, A.O.; Thomas, R.F.; Mercer, R.R.; Auten, R.L., 1999: Brief exposure to 95% oxygen alters surfactant protein D and mRNA in adult rat alveolar and bronchiolar epithelium. Surfactant protein D (SP-D), which has structural homology to C-type lectin binding regions, may play a role in host defense and has no known surfactant function. Because other surfactant proteins have been shown to be increased after prolonged pe...

Francoeur, A.; Pepin, D., 1978: Productivite de la fourmi Formica dakotensis dans le pessiere tourbeuse. 2. Variations annuelles de la densite des colonies, de l'occupation des nids et de la repartition spatiale. After 4 yr of production the mean density of F. dakotensis is 172.2 colonies/ha in the spruce bog of Saint-Ambroise, Quebec Canada . A variation index of 2% indicates that the colony population reached stability within the habitat. At the end of a...

Pavanelli, W., R.; Kaminami, M., S.; Geres, J., R.; Sano, A.-; Ono, M., A.; Camargo, I.C.C.; Itano, E., N., 2007: Protection induced in BALB. Paracoccidioidomycosis (PCM) is a granulomatous disease caused by a dimorphic fungus, Paracoccidioides brasiliensis. The present study investigated the protective activity of the P. brasiliensis high-molecular-mass (hMM) fraction (~380 kDa) in exp...