EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Relationship between human serum trypanocidal activity and host resistance to the African trypanosomes






Journal of Parasitology 79(2): 226-232

Relationship between human serum trypanocidal activity and host resistance to the African trypanosomes

Results reported here show that humans have various levels of (Trypanosoma brucei brucei) trypanocidal activity in their sera. This difference appeared stable when different samples were taken from the same individuals over time. It was not possible to account for the variability between individuals by obvious differences in health, nutrition, or living habits. In addition, the trypanocidal titers did not vary significantly when stored for various lengths of time at -70 degree C. To examine the relationship between titer of trypanocidal activity in a host and the degree of human serum resistance of the challenge trypanosome inoculum, mice (C57BL/6J) were pretreated with various amounts of different human serum and then infected with clones having different degrees of resistance to human serum. It was demonstrated that host susceptibility to an African trypanosome infection depends upon 2 variables: the level of trypanocidal activity in individual human serum and the degree of human serum resistance of individual clones of African trypanosomes. Based upon the animal model presented here, it is hypothesized that this relationship is under selective evolutionary pressure and will influence the susceptibility of animals in endemic areas as well as the transmission of human trypanosomiasis.

(PDF same-day service: $19.90)

Accession: 002477827

PMID: 8459333

DOI: 10.2307/3283512



Related references

The trypanocidal action of human serum The relationship between the trypanocidal action of the serum and mans immunity to the trypanosomes pathogenic for animals. 1934

The Trypanocidal Action of Normal Human Serum. The Nature of the Substance Responsible for the Trypanocidal Effect and its Relationship with the Bactericidal Activity of Normal Human Serum. Amer. J. Hyg, 21: 1-17, 1935

Evidence that low endocytic activity is not directly responsible for human serum resistance in the insect form of African trypanosomes. Bmc Research Notes 3(): 63-63, 2010

Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity. Eukaryotic Cell 10(8): 1023-1033, 2011

Host resistance to the African trypanosomes is interferon-gamma dependent. Journal of Allergy & Clinical Immunology 99(1 PART 2): S455, 1997

Evolution of the serum resistance-associated SRA gene in African trypanosomes. Chinese Science Bulletin 54(7): 1275-1278, 2009

Drug resistance in trypanosomes: selective interference with trypanocidal action. British Journal of Pharmacology and ChemoTherapy 14: 431-442, 1959

A note on the trypanosomes from the African freshwater fish and some comments on the possible relationship between taxonomy and pathology in trypanosomes. Bull. epizoot. Dis. Afr.: 18: 221-228, 1970

Note on the trypanosomes from the African freshwater fish and some comments on the possible relationship between taxonomy and pathology in trypanosomes. Bulletin of Epizootic Diseases of Africa. Bulletin des Epizooties en Afrique 18(3): 221-228, 1970

Activity and structure relationship of acridine derivatives against African trypanosomes. Tropical Medicine and Parasitology 46(1): 49-53, 1995