EurekaMag.com logo
+ Translate

Relationship between human serum trypanocidal activity and host resistance to the African trypanosomes


, : Relationship between human serum trypanocidal activity and host resistance to the African trypanosomes. Journal of Parasitology 79(2): 226-232

Results reported here show that humans have various levels of (Trypanosoma brucei brucei) trypanocidal activity in their sera. This difference appeared stable when different samples were taken from the same individuals over time. It was not possible to account for the variability between individuals by obvious differences in health, nutrition, or living habits. In addition, the trypanocidal titers did not vary significantly when stored for various lengths of time at -70 degree C. To examine the relationship between titer of trypanocidal activity in a host and the degree of human serum resistance of the challenge trypanosome inoculum, mice (C57BL/6J) were pretreated with various amounts of different human serum and then infected with clones having different degrees of resistance to human serum. It was demonstrated that host susceptibility to an African trypanosome infection depends upon 2 variables: the level of trypanocidal activity in individual human serum and the degree of human serum resistance of individual clones of African trypanosomes. Based upon the animal model presented here, it is hypothesized that this relationship is under selective evolutionary pressure and will influence the susceptibility of animals in endemic areas as well as the transmission of human trypanosomiasis.

(PDF same-day service: $19.90)

Accession: 002477827

PMID: 8459333

DOI: 10.2307/3283512

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Anonymous, 1934: The trypanocidal action of human serum The relationship between the trypanocidal action of the serum and mans immunity to the trypanosomes pathogenic for animals

Culbertson, J.T., 1934: The trypanocidal action of human serum: The relationship between the trypanocidal action of the serum and man's immunity to the trypanosomes pathogenic for man. Annals of Tropical Medicine and Parasitology, 28: 93-97

Culbertson, J.T.Strong, P.S., 1935: The trypanocidal action of normal human serum. The nature of the subatance responsible for the trypanocidal effect and its relationship with the bactericidal activity of normal human serum. American Journal of Hygiene, 21: 1-17

Culbertson, J.T.; Strong, P.S., 1935: The Trypanocidal Action of Normal Human Serum. The Nature of the Substance Responsible for the Trypanocidal Effect and its Relationship with the Bactericidal Activity of Normal Human Serum. This article records experiments carried out to investigate the nature of the trypanocidal substance of normal human serum. The authors consider that this substance is not identical with complement or any of the component parts of complement, as i...

Natesan, S.Ka.; Peacock, L.; Leung, K.Fai.; Gibson, W.; Field, M.C., 2010: Evidence that low endocytic activity is not directly responsible for human serum resistance in the insect form of African trypanosomes. In Trypanosoma brucei, the African trypanosome, endocytosis is developmentally regulated and substantially more active in all known mammalian infective stages. In both mammalian and insect stages endocytic activity is likely required for nutrient...

Stephens, N.A.; Hajduk, S.L., 2011: Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity. Trypanosoma brucei rhodesiense is the causative agent of human African sleeping sickness. While the closely related subspecies T. brucei brucei is highly susceptible to lysis by a subclass of human high-density lipoproteins (HDL) called trypanosom...

Hertz, C.J.; Mansfield, J.M., 1997: Host resistance to the African trypanosomes is interferon-gamma dependent. Journal of Allergy & Clinical Immunology 99(1 PART 2): S455

DeHua Lai; QiaoPing Wang; Zhi Li; Lukeš Julius; ZhaoRong Lun, 2009: Evolution of the serum resistance-associated SRA gene in African trypanosomes. Serum resistance-associated (SRA) protein, a protein unique for Trypanosoma brucei rhodesiense, is responsible for resistance of this parasite to the lysis by normal human serum (NHS) and is a vital molecular marker to distinguish this species fro...

Williamson, J., 1959: Drug resistance in trypanosomes: selective interference with trypanocidal action. II. Selective reversal of the trypanocidal action of carboxylated arsenicals by p-aminobenzoic acid and of melaminyl arsenicals and diamidines by melamine has been demonstrated. These reversals reflect the pattern of cross-resistance behaviour and...

Williamson, J., 1959: Drug resistance in trypanosomes. II. Selective interference with trypanocidal action. II. Selective reversal of the trypanocidal action of carboxylated arsenicals by p-aminobenzoic acid and of melaminyl arsenicals and diamidines by melamine has been demonstrated. These reversals reflect the pattern of cross-resistance behaviour and...