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Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics

, : Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics. Veterinary Parasitology 49(2-4): 123-158

The purpose of this review article is to establish a relationship between pharmacological properties and clinical efficacy of the most widely used broad-spectrum veterinary anthelmintics. The impact of drug pharmacokinetics/pharmacodynamics on anthelmintic efficacy and resistance is discussed. We review the clinical pharmacokinetics of the currently available anthelmintics used in livestock-imidazothiazoles, tetrahydropyrimidines, benzimidazoles/pro-benzimidazoles, salicylanilides (closantel) and avermectin-type compounds. Understanding the pharmacokinetics and metabolic behaviour of broad-spectrum anthelmintics in the host, and factors modulating that behaviour, is highly important for maximizing anthelmintic utility and efficacy.

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Accession: 002477914

PMID: 8249240

DOI: 10.1016/0304-4017(93)90115-4

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Chereskin, B.M.; Gantt, E., 1986: Enrichment of a 50 kilodalton polypeptide in a photosystem ii phycobilisome particle from porphyridium cruentum. A 50-kDa polypeptide was obtained from photosynthetically active phycobilisome-photosystem II preparations from the red alga Porphyridium cruentum after removal of phycobiliproteins. Removal of phycobiliproteins caused destabilization of the struc...

Houdemer; Bablet, 1927: Lymphoblastoma of the inguinal region in an An-namese dog. An encapsuled tumor of the inguinal lymph nodes was removed from an 18-month-old dog. It differed from infectious genital tumors common in Indo-China. Histologically the tumor proved to be benign. The nuclei in the cells were enlarged; nucleoli we...

Shumann K.; Baumann A.; Nagl W., 1990: Localization of phaseolin genes in the polytene chromosomes of phaseolus coccineus leguminosae. The location of the genes for the major storage protein, phaseolin, was determined in the polytene chromosome of the embryo-suspensor of Phaseolus coccineus. cv. Hammond's Dwarf Scarlett, by in situ hybridization with a 35S-labelled cloned pr...

Rubin, H.R.; Redelmeier, D.A.; Wu, A.W.; Steinberg, E.P., 1993: How reliable is peer review of scientific abstracts? Looking back at the 1991 Annual Meeting of the Society of General Internal Medicine. To evaluate the interrater reproducibility of scientific abstract review. Retrospective analysis. Review for the 1991 Society of General Internal Medicine (SGIM) annual meeting. 426 abstracts in seven topic categories evaluated by 55 reviewers. Re...

Caramella, T.; Fuerxer, F.; Chevallier, P.; Cua, E.; Saint Paul, M.C.; Dausse, F.; Novellas, S.; Gueyffier, C.; Brunner, P.; Bruneton, J.N., 2007: MR Features of hepatic macronodular mycobacteriosis. Hepatic macronodular mycobacteriosis is rare. Its diagnosis is challenging and is most often proposed on the basis of histological analysis. Final diagnosis, except for germ-proven cases, is made in conjunction with clinical, biological, and radio...

Grufferman, S.; Markle, W.H.; Middleton, D.B., 1995: Worms and the historical overload syndrome. Journal of Family Practice 41(5): 431-431

Starrett, J.E.Jr; Tortolani, D.R.; Hitchcock, M.J.M.; Martin, J.C.; Mansuri, M.M., 1992: Synthesis and in vitro evaluation of a phosphonate prodrug bis -9- adenine. 9-(2-Phosphonylmethoxyethyl)adenine (PMEA: 1) was acylated with chloromethyl pivalate to afford bis(pivaloyloxymethyl) PMEA (2). The ester prodrug demonstrated enhanced in vitro potency against HSV-2 greater than 150-fold higher than the parent co...

Sugioka, K.; Cheng, Y.; Midorikawa, K.; Takase, F.; Takai, H., 2006: Femtosecond laser microprocessing with three-dimensionally isotropic spatial resolution using crossed-beam irradiation. We describe the use of a crossed-beam irradiation system in three-dimensional femtosecond laser microprocessing to obtain three-dimensionally isotropic spatial resolution. In the crossed-beam geometry, two orthogonal objective lenses are arranged...

Thiaucourt, P., 1985: Note sur le genre Pauluma Schaus (Lep., Notodontidae). Lambillionea, 855-6: 35-41

Wang, J.; Pumera, M., 2002: Dual conductivity/amperometric detection system for microchip capillary electrophoresis. The performance characteristics and advantages of a new dual electrochemical microchip detection system based on simultaneous conductivity and amperometric measurements are described. The system relies on the combination of a contactless conductiv...