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Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics

, : Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics. Veterinary Parasitology 49(2-4): 123-158

The purpose of this review article is to establish a relationship between pharmacological properties and clinical efficacy of the most widely used broad-spectrum veterinary anthelmintics. The impact of drug pharmacokinetics/pharmacodynamics on anthelmintic efficacy and resistance is discussed. We review the clinical pharmacokinetics of the currently available anthelmintics used in livestock-imidazothiazoles, tetrahydropyrimidines, benzimidazoles/pro-benzimidazoles, salicylanilides (closantel) and avermectin-type compounds. Understanding the pharmacokinetics and metabolic behaviour of broad-spectrum anthelmintics in the host, and factors modulating that behaviour, is highly important for maximizing anthelmintic utility and efficacy.

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Accession: 002477914

PMID: 8249240

DOI: 10.1016/0304-4017(93)90115-4

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