+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Relationship between sensitivity to dietary fat and dietary cholesterol

Arteriosclerosis 10(3): 394-401
Relationship between sensitivity to dietary fat and dietary cholesterol
A group of 56 hypercholesterolemic and normocholesterolemic men and women were given approximately 700 mg a day of egg yolk cholesterol in a double-blind, crossover study while they were on a background diet containing approximately 30% of energy as fat. Overall there was a 0.23 mmol/l rise in plasma cholesterol (3.7%, p < 0.001) after 4 weeks, a 0.19 mmol/l rise in low density lipoprotein (LDL) cholesterol (4.9%, p = 0.002), and a 0.07 mmol/l rise in high density lipoprotein (HDL) cholesterol (5.4%, p < 0.001). Plasma triglycerides fell by 0.07 mmol/l (5.1%). Normocholesterolemic individuals (plasma cholesterol < 5.2 mmol/l) experienced small, nonsignificant rises of 0.06, 0.02, and 0.05 mmol/l in total, LDL, and HDL cholesterol, respectively. Hypercholesterolemic subjects were classified on the basis of their response to a low fat diet. Diet-sensitive subjects were defined by a > 10% fall in plasma cholesterol on a 25% fat, low cholesterol (< 200 mg/day) diet. These individuals were found to be more responsive to the effect of dietary cholesterol than were diet-insensitive subjects; the respective changes in the two groups were rises of 0.36 mmol/l versus 0.19 mmol/l in plasma cholesterol (p = 0.06) and rises of 0.30 versus 0.15 mmol/l in LDL cholesterol (p = 0.06). In addition to elevating HDL cholesterol by 0.09 mmol/l and 0.07 mmol/l, respectively, dietary cholesterol also produced an increase in the proportion of HDL2, from 40% to 44% of HDL protein (p < 0.001). The change in both LDL and HDL cholesterol with dietary cholesterol supplementation was related to the change with fat supplementation (r = 0.35, p < 0.05 and r = 0.45, p < 0.001, respectively). However, normocholesterolemic individuals who are not particularly responsive to dietary cholesterol may, nevertheless, also need to consider such restrictions, especially if they are at risk for atherosclerosis.

Accession: 002477973

PMID: 2344298

DOI: 10.1161/01.ATV.10.3.394

Related references

Relationship between sensitivity to dietary fat and sensitivity to dietary cholesterol in normal and hypercholesterolemic subjects. Circulation 80(4 SUPPL 2): II379, 1989

Plasma and dietary cholesterol in infancy: effects of early low or moderate dietary cholesterol intake on subsequent response to increased dietary cholesterol. Metabolism 21(12): 1181-1192, 1972

U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans. Journal of Lipid Research 39(12): 2415-2422, 1998

Methodology Of Dietary Surveys Associated With Epidemiological Research On The Relationship Between Serum-Cholesterol And Dietary Fat. Bibliotheca Nutritio et Dieta 6: 52-62, 1964

Dietary cholesterol-induced down-regulation of intestinal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity is diminished in rabbits with hyperresponse of serum cholesterol to dietary cholesterol. Journal of Nutrition 123(4): 695-703, 1993

Dietary fats modulate the regulatory potential of dietary cholesterol on cholesterol on cholesterol 7-alpha-hydroxylase gene expression. Journal of Lipid Research 38(2): 315-323, 1997

U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary absorption in humans. Journal of lipid research 39(12): 2415-2422, 1998

Relation between the response of serum cholesterol to dietary cholesterol and to the type of dietary fat, protein and fiber in hypo- and hyperresponsive rats. Nutrition Reports International 29(6): 1369-1381, 1984

Hypercholesterolemic effect of dietary cholesterol in diets enriched in polyunsaturated and saturated fat. Dietary cholesterol, fat saturation, and plasma lipids. Arteriosclerosis and Thrombosis 14(1): 168-175, 1994

Dietary advice in hypercholesterolemia the relationships of selected dietary factors to the total serum cholesterol and high density lipoprotein cholesterol. Ugeskrift for Laeger 151(35): 2206-2210, 1989