EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Relationship between sensitivity to dietary fat and dietary cholesterol


, : Relationship between sensitivity to dietary fat and dietary cholesterol. Arteriosclerosis 10(3): 394-401

A group of 56 hypercholesterolemic and normocholesterolemic men and women were given approximately 700 mg a day of egg yolk cholesterol in a double-blind, crossover study while they were on a background diet containing approximately 30% of energy as fat. Overall there was a 0.23 mmol/l rise in plasma cholesterol (3.7%, p < 0.001) after 4 weeks, a 0.19 mmol/l rise in low density lipoprotein (LDL) cholesterol (4.9%, p = 0.002), and a 0.07 mmol/l rise in high density lipoprotein (HDL) cholesterol (5.4%, p < 0.001). Plasma triglycerides fell by 0.07 mmol/l (5.1%). Normocholesterolemic individuals (plasma cholesterol < 5.2 mmol/l) experienced small, nonsignificant rises of 0.06, 0.02, and 0.05 mmol/l in total, LDL, and HDL cholesterol, respectively. Hypercholesterolemic subjects were classified on the basis of their response to a low fat diet. Diet-sensitive subjects were defined by a > 10% fall in plasma cholesterol on a 25% fat, low cholesterol (< 200 mg/day) diet. These individuals were found to be more responsive to the effect of dietary cholesterol than were diet-insensitive subjects; the respective changes in the two groups were rises of 0.36 mmol/l versus 0.19 mmol/l in plasma cholesterol (p = 0.06) and rises of 0.30 versus 0.15 mmol/l in LDL cholesterol (p = 0.06). In addition to elevating HDL cholesterol by 0.09 mmol/l and 0.07 mmol/l, respectively, dietary cholesterol also produced an increase in the proportion of HDL2, from 40% to 44% of HDL protein (p < 0.001). The change in both LDL and HDL cholesterol with dietary cholesterol supplementation was related to the change with fat supplementation (r = 0.35, p < 0.05 and r = 0.45, p < 0.001, respectively). However, normocholesterolemic individuals who are not particularly responsive to dietary cholesterol may, nevertheless, also need to consider such restrictions, especially if they are at risk for atherosclerosis.


Accession: 002477973

PMID: 2344298

DOI: 10.1161/01.ATV.10.3.394

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Clifton P.M.; Kestin M.; Abbey M.; Nestel P.J., 1989: Relationship between sensitivity to dietary fat and sensitivity to dietary cholesterol in normal and hypercholesterolemic subjects. Circulation 80(4 SUPPL 2): II379

Glueck, C.J.; Tsang, R.; Balistreri, W.; Fallat, R., 1972: Plasma and dietary cholesterol in infancy: effects of early low or moderate dietary cholesterol intake on subsequent response to increased dietary cholesterol. Studies were made during the first year of life on 21 normal and 18 hypercholesterolaemic infants to find whether the amount of dietary cholesterol in early infancy affects subsequent adaptation to dietary cholesterol in later infancy and childhoo...

Sehayek, E.; Nath, C.; Heinemann, T.; McGee, M.; Seidman, C.E.; Samuel, P.; Breslow, J.L., 1998: U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans. A possible relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness was examined in 18 normal subjects fed low fat low cholesterol, high fat low cholesterol, and high fat high cholesterol diets. For the g...

De.H.Rtog.C.; Va.S.Haikt.D.Lderup.L.M.; Drion.E., 1964: Methodology Of Dietary Surveys Associated With Epidemiological Research On The Relationship Between Serum-Cholesterol And Dietary Fat. Bibliotheca Nutritio et Dieta 6: 52-62

Meijer, G.W.; Smit, M.J.; Van Der Palen, J.G.; Kuipers, F.; Vonk, R.J.; Van Zutphen, B.F.; Beynen, A.C., 1993: Dietary cholesterol-induced down-regulation of intestinal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity is diminished in rabbits with hyperresponse of serum cholesterol to dietary cholesterol. Key enzymes of cholesterol metabolism were studied in two inbred strains of rabbits with hyper- or hyporesponse of serum cholesterol to dietary cholesterol. Baseline 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity in liver was similar in h...

Cheema, S.K.; Cikaluk, D.; Agellon, L.B., 1997: Dietary fats modulate the regulatory potential of dietary cholesterol on cholesterol on cholesterol 7-alpha-hydroxylase gene expression. Cholesterol 7-alpha-hydroxylase (cyp7) is the rate-limiting enzyme in bile acid biosynthesis. Previously, dietary cholesterol was shown to induce cyp7 gene expression. However, recent studies have produced data that are inconsistent with this obse...

Sehayek, E.N.th, C.H.inemann, T.M.gee, M.S.idman, C.; Samuel, P.B.eslow, J., 1998: U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary absorption in humans. Journal of lipid research 39(12): 2415-2422

Beynen, A.C.; Katan, M.B., 1984: Relation between the response of serum cholesterol to dietary cholesterol and to the type of dietary fat, protein and fiber in hypo- and hyperresponsive rats. A diet containing 2% (w/w) cholesterol and 0.5% cholate given to male rats, when compared to a commercial diet, caused an increase in serum cholesterol by about 1 mmol/litre in a hyporesponsive inbred strain and by about 10 mmol/litre in a hyperre...

Lichtenstein, A.H.; Ausman, L.M.; Carrasco, W.; Jenner, J.L.; Ordovas, J.M.; Schaefer, E.J., 1994: Hypercholesterolemic effect of dietary cholesterol in diets enriched in polyunsaturated and saturated fat. Dietary cholesterol, fat saturation, and plasma lipids. Within the context of reduced-fat diets, the effects of incorporating a fat high in stearic acid and adding moderate amounts of dietary cholesterol were examined in 14 middle-aged and elderly women and men (range, 46 to 78 years) with low-density...

Andersen M.M.; Ebbesen K.; Hess K.; Idorn M L.; Simony K., 1989: Dietary advice in hypercholesterolemia the relationships of selected dietary factors to the total serum cholesterol and high density lipoprotein cholesterol. Forty patients (14 women and 26 men) with slight to moderate hypercholesterolaemia received dietary advice and were followed-up for 12 weeks, the majority for 26 weeks. After 12 weeks, the total cholesterol had decreased by an average of 12% (from...