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The biology of Sry

The biology of Sry

Seminars in Developmental Biology 2(4): 259-264

A review. The sex-determining region on the Y-chromosome (Sry) in mice maps to the smallest region of the Y-chromosome known to be sex-determining. It is also deleted in a line of XY mice which are all and are known to have a mutation within the testis-determining gene (Tdy). Sequence comparison indicates that Sry may be a transcription factor and a member of a family of related mouse genes.

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