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The urinary excretion of thiobarbituric acid reactive substances and malondialdehyde by normal adult males after consuming a diet containing salmon


, : The urinary excretion of thiobarbituric acid reactive substances and malondialdehyde by normal adult males after consuming a diet containing salmon. Lipids 28(8): 757-761

In this study we investigated the output of thiobarbituric acid reactive substances (TBARS) and malondialdehyde (MDA), as thiobarbituric acid (TBA)-MDA adduct, in the urine from subjects eating a diet in which the only source of n-3 long-chain, polyunsaturated fatty acids was fresh salmon. Nine healthy men, ages 30-65, were confined in the United States Department of Agriculture Western Human Nutrition Research Center, San Francisco, CA, for 100 d; food intake and exercise levels were controlled. All subjects were placed on a stabilization diet (StD) for 20 d, then six were fed the salmon diet for 40 d. The others remained on the StD. The groups switched diets for the primarily eicosapentaenoic acid and docosahexaenoic acid in a 50:60 ratio, while the StD contained 7.5% from n-6 FAs and lt 0.3% n-3 FAs (with presumably no significant amounts of C-20 or C-22 n-3 FAs). Twenty-four hour urinary output was collected, and 2% 3-d pool samples prepared for analysis of urinary TBARS and the TBA-MDA adduct. The total urinary output of each individual varied considerably, and on a daily basis the concentration of autoxidation products in an individual's urine varied also. However, the mean daily output (in mu-moles TBA-MDA equivalents/day) at the end of the salmon diet feeding period was significantly greater (7.05 +- 1.33 TBARS, P lt 0.05; and 7.07 +- 1.73 TBA-MDA adduct, P lt 0.01) compared to when the subjects were eating the StD (5.65 +- 1.09 TBARS and 4.65 +- 0.76 TBA-MDA adduct). When the TBARS and TBA-MDA adduct values were normalized relative to creatinine output (in nmoles TBA-MDA equivalents/mu-mole creatinine), the data achieved even greater statistical significance. The mean output of the group eating the salmon diet was 0.478 +- 0.076 for TBARS (P lt 0.01) and 0.476 +- 0.082 for the TBA-MDA adduct (P lt 0.001) vs. 0.345 +- 0.059 for TBARS and 0.283 +- 0.041 for the TBA-MDA adduct when the subjects were consuming the StD. Thus, the consumption of cooked fish may increase one's exposure to AMA and other autoxidation products, compounds that may be carcinogenic or mutagenic.

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Accession: 002530013

PMID: 8377591

DOI: 10.1007/bf02536000

PDF Full Text: The urinary excretion of thiobarbituric acid reactive substances and malondialdehyde by normal adult males after consuming a diet containing salmon


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