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The use of transgenic animals as novel expression systems for the production of human recombinant antiproteases and complex coagulation factors

, : The use of transgenic animals as novel expression systems for the production of human recombinant antiproteases and complex coagulation factors. Biotechnology international: 80-83

This paper reviews the trans-immortalisation procedure by which cell lines can be established from transgenic mice, using oncogenes to mediate immortalisation of the lines. A gene encoding for a protein product of interest is transferred into mice along with an oncogene. The mice develop tumours, from which the immortalised cell lines expressing the recombinant protein are established.

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