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The uterine relaxant effect of Aloe chabaudii


, : The uterine relaxant effect of Aloe chabaudii. Fitoterapia 65(3): 253-259

A crude extract of the leaves of A. chabaudii inhibited the spontaneous contractions of the isolated rat uterus. The inhibitory effect (lid not appear to be due to its content of potassium ions nor due to stimulation of beta-2-receptors since propranolol which blocked isoprenaline-induced relaxation on the uterus had no effect on the aloe-induced inhibitory response. A non-specific membrane depressant effect is also not likely since the aloe extract had no effect on the contractile response to acetylcholine and oxytocin. The possibility of the aloe action on H-2 receptors is discussed as well as its possibility in blocking the phosphodiesterase enzyme and thereby increasing intracellular cyclic AMP. A. chabaudii therefore does not possess abortifacient activity and should not be used for this purpose.

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