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The utilization of quantitative trait loci in toxicogenetics

, : The utilization of quantitative trait loci in toxicogenetics. Journal of Experimental Animal Science 35(5-6): 251-258

The principles underlying the use of recombinant inbred strains of laboratory mammals to map quantitative trait loci (QTL) are explained, and the relevance of these methods in mapping QTL of toxicological significance is discussed.

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McClearn, G.E.; Jones, B.; Blizard, D.A.; Plomin, R., 1993: The utilization of quantitative trait loci in toxicogenetics. With the increasing number of marker loci available in mouse, the traditional method of recombinant inbred strains can be extended to searches for quantitative trait loci (QTL) influencing continuously distributed phenotypes. These loci have effec...

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