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The vertebrate genome: isochores and chromosomal bands


, : The vertebrate genome: isochores and chromosomal bands. Chromosomes today: volume 11: 49-60

A discussion. The genome of warm-blooded vertebrates appears to comprise a 'palaeogenome', characterised by GC-poor isochores which have not changed in composition relative to the corresponding isochores of cold-blooded vertebrates, and a 'neogenome', characterised by isochores which have become GC-rich.

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Related references

Saccone, S.; D.S.rio, A.; Wiegant, J.; Raap, A.K.; Della Valle, G.; Bernardi, G., 1993: Correlations between isochores and chromosomal bands in the human genome. The human genome is made up of long DNA segments, the isochores, which are compositionally homogeneous and can be subdivided into a small number of families characterized by different G+C levels. Chromosome in situ suppression hybridization (in wh...

Costantini, M.; Bernardi, G., 2008: Replication timing, chromosomal bands, and isochores. Chromosome replication timing is biphasic (early-late) in the cell cycle of vertebrates and of most (possibly all) eukaryotes. In the present work we have compared the extended, detailed replication timing maps that are available, namely those of...

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Saccone, S.; Pavlicek, A.; Federico, C.; Paces, J.; Bernardi, G., 2001: Genes, isochores and bands in human chromosomes 21 and 22. The recently available DNA sequences from chromosomes 21 and 22 enabled us to define the relationships of different band types with isochores and with gene concentration and to compare these relationships with previous results. We showed that chro...

Mitelman F.; Heim S., 1988: Consistent involvement on only 71 of the 329 chromosomal bands of the human genome in primary neoplasia associated rearrangements. In an attempt to quantify the nonrandomness of primary neoplasia-associated acquired chromosomal aberrations in humans, we have retrieved information from a computerized data base on the chromosomal abnormalities of 9069 human neoplasms. By restri...

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Costantini, M.; Greif, G.; Alvarez-Valin, F.; Bernardi, G., 2016: The Anolis Lizard Genome: An Amniote Genome without Isochores?. Two articles published 5 years ago concluded that the genome of the lizard Anolis carolinensis is an amniote genome without isochores. This claim was apparently contradicting previous results on the general presence of an isochore organization in...

Cacciò, S.; Jabbari, K.; Matassi, G.; Guermonprez, F.; Desgrès, J.; Bernardi, G., 1998: Methylation patterns in the isochores of vertebrate genomes. 5-Methylcytosine (5mC) levels were determined in compositional DNA fractions corresponding to different isochore families from the genomes of Xenopus, chicken, mouse and human, four vertebrates which show different isochore patterns. The results o...