EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Zinc distribution in blood components, inflammatory status, and clinical indexes of disease activity during zinc supplementation in inflammatory rheumatic diseases


American Journal of Clinical Nutrition 57(5): 690-694
Zinc distribution in blood components, inflammatory status, and clinical indexes of disease activity during zinc supplementation in inflammatory rheumatic diseases
The effects of zinc supplementation on zinc status and on clinical and biological indicators of inflammation were investigated in 18 patients with chronic inflammatory rheumatic diseases and in 9 healthy control subjects. Patients with mild and recent onset disease were assigned to a 60-d trial to receive either 45 mg Zn (as gluconate)/d or a placebo, while control subjects received the zinc supplement. Baseline mean plasma zinc of the patients was low whereas mononuclear cell zinc content was elevated, suggesting a redistribution of the element related to the inflammatory process rather than to a zinc-deficient state. Zinc supplementation increased plasma zinc to a similar extent in patients and in control subjects, which suggested no impairment of zinc intestinal absorption as a result of the inflammatory process. On the contrary, erythrocyte and leukocyte zinc concentrations were not modified in the two groups examined. No beneficial effect of zinc treatment could be demonstrated on either clinical or inflammation indexes.


Accession: 002549134

PMID: 8480688



Related references

Effects of zinc supplementation on the phagocytic functions of polymorphonuclears in patients with inflammatory rheumatic diseases. Journal of Trace Elements and Electrolytes in Health and Disease 8(3-4): 189-194, 1994

Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status. Molecular Nutrition & Food Research 59(6): 1200-1212, 2016

Zinc copper and selenium in chronic and acute inflammatory rheumatic diseases. Braetter, P And P Schramel (Ed ) Trace Element Analytical Chemistry in Medicine And Biology Proceedings Of International Workshop, Vol 5; Neuherberg, West Germany, April Xix+666p Walter De Gruyter And Co : Berlin, West Germany; Hawthorne, New York, Usa Illus 471-476, 1988

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation. Biofactors 41(6): 414-423, 2016

Effect of zinc supplementation on red blood cell zinc, serum zinc, taste acuity, and dietary intake in zinc deficient dialysis patients. Dialysis and Transplantation 7(12): 1208-1210, 1213, 1978

Zinc status in inflammatory bowel disease. Clinical Science 75(3): 277-283, 1988

Effects of modulation of inflammatory and immune parameters in patients with rheumatic and inflammatory disease receiving dietary supplementation of n-3 and n-6 fatty acids. Lipids 31(SUPPL ): S243-S247, 1996

Associations among dietary zinc intakes and biomarkers of zinc status before and after a zinc supplementation program in Guatemalan schoolchildren. Food and Nutrition Bulletin 34(2): 143-150, 2013

Analysis of zinc in blood cellular components as a means of assessment of zinc status. Trace elements in man and animals: TEMA 5: proceedings of the fifth International Symposium on Trace Elements in Man and Animals editors CF Mills I Bremner and JK Chesters: 594, 1985

The effect of zinc supplementation during lactation on maternal zinc status and milk zinc concentrations. FASEB Journal 5(5): A1289, 1991