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Alpha 1,3galactosyltransferase: a target for in vivo genetic manipulation in xenotransplantation


, : Alpha 1,3galactosyltransferase: a target for in vivo genetic manipulation in xenotransplantation. Immunological Reviews 141: 59-70

This review discusses (1) evidence supporting the view that alpha 1,3galactosyltransferase, which is present in pig cells but is absent in human cells, is responsible for the rejection response by humans against pig tissue transplants, (2) studies on nucleotide sequences of the pig, mouse and cattle alpha 1,3galactosyltransferase gene and the alpha 1,3galactosyltransferase pseudogene in humans, (3) phylogenetic relationships between the alpha 1,3galactosyltransferase sequences of some non-human mammals and sequences for the human A transferase and the human alpha 1,3galactosyltransferase pseudogene, and (4) molecular methods of reducing the expression of the alpha 1,3galactosyltransferase epitope in pigs.

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Accession: 002549293

PMID: 7532619

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Related references

Strahan, K.; Preece, A.; Gustafsson, K., 1996: Pig alpha1, 3galactosyltransferase: a major target for genetic manipulation in xenotransplantation. Terminal carbohydrate residues of glycolipids and glycoproteins display polymorphism among as well as within various species. With the exception of Old World monkeys, great apes and man, the Gala1,3Gal structure is widely expressed in all mammals...

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Cooper, D.K.C.; Koren, E.; Oriol, R., 1996: Manipulation of the anti-alpha-Gal antibody-alpha-Gal epitope system in experimental discordant xenotransplantation. In 1991, evidence was provided to indicate that hyperacute rejection of pig organs by humans and baboons was initiated by the binding of anti-alpha-galactosyl (alpha-Gal) antibodies to the vascular endothelium. A search for suitable donor species...

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