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Beta -Adrenoceptor blockage and skeletal muscle energy metabolism during endurance exercise

, : Beta -Adrenoceptor blockage and skeletal muscle energy metabolism during endurance exercise. Journal of Applied Physiology 78(1): 307-313

12 healthy male subjects (21-31 years old) cycled to exhaustion at a workload corresponding to 70% of maximal aerobic power after administration of the beta 1+2-adrenoceptor antagonist propranolol 80 mg and after administration of placebo orally. Exercise times until exhaustion were 39+or-7 and 86+or-7 min in the propranolol and placebo groups, respectively. Muscle inosine 5'-monophosphate content was significantly increased above resting levels at exhaustion after placebo.

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