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1'-(2-phenyl-ethylene)-ditryptophenaline, a new dimeric diketopiperazine from Aspergillus flavus


Journal of Natural Products 57(9): 1239-1244
1'-(2-phenyl-ethylene)-ditryptophenaline, a new dimeric diketopiperazine from Aspergillus flavus
A new diketopiperazine dimer, 1'-(2-phenyl-ethylene)-ditryptophenaline [1], was isolated together with ditryptophenaline [2] from the fungus Aspergillus flavus. The structure of 1 was determined by analysis of spectroscopic data. In contrast to the structurally related substance-P antagonist WIN 64821 [3], both 1 and 2 are weak substance-P inhibitors, indicating that stereochemistry at the position of dimerization is an important determinant of biological potency for these molecules.

Accession: 002549647

PMID: 7528269

DOI: 10.1021/np50111a008

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