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2,7-Dihydroxyapogeissoschizine from root bark of Strychnos gossweileri


, : 2,7-Dihydroxyapogeissoschizine from root bark of Strychnos gossweileri. Phytochemistry (Oxford) 35(2): 533-536

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on ID and 2DNMR studies; its conformation was optimized by energy minimization. According to a preliminary test, this substance shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.

Accession: 002549857

DOI: 10.1016/s0031-9422(00)94796-4

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Related references

Coune, C., 1978: New alkaloids of Strychnos gossweileri. The roots of S. gossweileri yielded 5 indole alkaloids, namely dolichantoside, diploceline, alstonine, strychnochromine and strychnoxanthine. The structures of the last 2 compounds were determined.

Coune, C.; Angenot, L., 1978: Dolichantoside a new alkaloid from strychnos gossweileri. The isolation and the structure elucidation of a new indole glucoalkaloid extracted from the roots of S. gossweileri collected in Zaire are reported.

Coune, C., 1978: New alkaloids of Strychnos gossweileri Exell. Plantes medicinales et phytotherapie 12(2): 106-111

Coune, C.A.; Angenot, L.J.G., 1978: Diploceline a new alkaloid of strychnos gossweileri. The elucidation of the chemical structure of the quaternary alkaloid, diploceline, which represents the major alkaloidal ingredient of S. gossweileri is the object of this article. The plant yielding this substance was collected in Zaire. Previous...

Coune, C.A.; Angenot, L.J.G., 1980: The minor alkaloids of Strychnos gossweileri. In addition to alstonine, dolichantoside and diploceline, which had all been reported earlier, the new alkaloids isodolichantoside, strychnofluorine and 16-epi-diploceline were isolated from the root of bark of S. gossweileri.

Coune C.A., 1979: The minor alkaloids of strychnos gossweileri. Planta Medica 36(3): 297-298

Coune, C.; Angenot, L., 1978: Diploceline, a new alkaloid from Strychnos gossweileri

Coune, C., 1978: Data on new alkaloids from strychnos gossweileri. From the roots of S. gossweileri Exell., 5 indole alkaloids were extracted: dolichantoside, a new glucoalkaloid; diploceline, a new quaternary alkaloid; and alstonine, an anhydronium base. The structures of 2 other new alkaloids, strychnochromine...

Quetin-Leclercq, J.C.ucke, P.D.laude, C.W.rin, R.B.ssleer, R.A.genot, L., 1991: Matadine, a cytotoxic alkaloid from Strychnos gossweileri. Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on ID and 2D NMR studies. Its cytotoxic activity has been tested in vitro on cancer cells and normal cells.

Coune, C.A.genot, L., 1978: Dolichantoside, a new alkaloid from Strychnos gossweileri Exell