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2,7-Dihydroxyapogeissoschizine from root bark of Strychnos gossweileri






Phytochemistry (Oxford) 35(2): 533-536

2,7-Dihydroxyapogeissoschizine from root bark of Strychnos gossweileri

In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on ID and 2DNMR studies; its conformation was optimized by energy minimization. According to a preliminary test, this substance shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.

Accession: 002549857

DOI: 10.1016/s0031-9422(00)94796-4

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