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Dehydroepiandrosterone and macronutrient selection by obese Zucker rats (fa/fa)


, : Dehydroepiandrosterone and macronutrient selection by obese Zucker rats (fa/fa). Appetite 25(2): 143-154

The effect of dehydroepiandrosterone (DHEA) on the macronutrient preference and total energy intake of lean and obese female Zucker rats was studied. Introduction of DHEA led to a rapid decrease in the consumption of fat, protein and total calories by the obese rat. DHEA treatment of the lean rat caused a change neither in its total energy consumption nor in its fat consumption, but did cause a distinct expression of preference for carbohydrate over protein. Both lean and obese animals gained weight rapidly during the steroid-free weeks and lost weight while consuming the DHEA-supplemented diet. The difference in weight changes seen with the obese rats between the DHEA-free and DHEA-supplemented periods could be accounted for by differences in caloric intake. Lean rats, however, did not change their total energy intake during DHEA-treatment periods; therefore, DHEA caused weight loss in the lean rat probably by altering energy metabolism. It is concluded that in the obese, young, female Zucker rat, DHEA alters macronutrient preference as well as caloric intake. In the lean rat, DHEA has a more subtle effect on relative macronutrient preference and not on total energy consumption.

Accession: 002590160

PMID: 8561487

DOI: 10.1006/appe.1995.0051

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Related references

Svec, F.A.adie, J.B.owne, E.; Porter,. Jr.;, 1995: Dehydroepiandrosterone and macronutrient selection by obese Zucker rats (fa. The effect of dehydroepiandrosterone (DHEA) on the macronutrient preference and total energy intake of lean and obese female Zucker rats was studied. Introduction of DHEA led to a rapid decrease in the consumption of fat, protein and total calorie...

Wright, B.E.; Svec, F.; Porter, J.R., 1992: Effect of parenteral dehydroepiandrosterone on body weight and macronutrient selection in Zucker rats. Clinical Research 40(4): 834A

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Rouru, J.; Huupponen, R.; Santti, E.; Koulu, M., 1993: Effect of subchronic metformin treatment in macronutrient selection in genetically obese Zucker rats. Metformin has been particularly recommended to be used in obese type 2 diabetic patients because of its weight decreasing and serum lipid profile normalizing effects. In the present study the effects of subchronic metformin treatment on macronutri...

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Wright B.E.; Porter J.R.; Svec F., 1990: Dehydroepiandrosterone an antiglucocorticoid in young obese zucker rats. Clinical Research 38(4): 943A

Svec, F.; Porter, J., 1996: Effect of DHEA on macronutrient selection by Zucker rats. Zucker rats are a frequently used model in obesity research. Dehydroepiandrosterone (DHEA) reduces their rate of weight gain and caloric consumption. So far, most studies have been conducted while the animals consume laboratory rodent chow, which...

Svec, F.; Porter, J., 1996: Effects of DHEA on macronutrient selection by Zucker rats. Zucker rats are a frequency used model in obesity research. Dehydroepiandrosterone (DHEA) reduces their rate of weight gain and energy consumption. In this study, Zucker rats were offered fat as a food choice. The goal was to determine how the con...