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Delayed effects of exposure to organophosphorus compounds

, : Delayed effects of exposure to organophosphorus compounds. Indian Journal of Medical Research 101: 81-84

In a group of 34 industrial workers, chronically exposed to organophosphorus (OP) compounds, serum pseudocholinesterase activity was depressed significantly in the exposed group as compared to the control group. There was a significantly higher incidence of peripheral neuropathy among the workers exposed to OP compounds, as compared to the control group. Mild to profound sensorineural hearing deficits were detected in both the exposed and control groups. As the pre-exposure hearing status of the workers was not known and since many other factors can also cause pathological changes in the cochlear nerve, a definite conclusion about the ototoxic nature of the OP compounds could not be drawn.

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Accession: 002590181

PMID: 7729854

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Related references

Aldridge, W.N.; Johnson, M.K., 1971: Side effects of organophosphorus compounds: delayed neurotoxicity. Many organophosphorus compounds produce a chronic toxicity that has been classified as a dying-back process in which the long axons are particularly affected. Recent evidence indicates that an essential first step in the production of the lesion i...

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