EurekaMag.com logo
+ Translate

Delta-opioid peptide receptors in muscles from obese diabetic and normal mice


, : Delta-opioid peptide receptors in muscles from obese diabetic and normal mice. Peptides (Tarrytown) 16(2): 361-364

Autoradiography was used to study the opioid receptors in soleus and extensor digitorum longus (EDL) muscles from normal mice and mice with type II diabetes. Binding sites for (125I)beta-endorphin were present on the surface membranes in muscles from normal mice. The density of receptors was higher in muscles from obese diabetic mice. The specific delta-opioid ligands DPDPE and (D-Ala-2)deltorphin-II inhibited the binding of (125I)beta-endorphin whereas mu and kappa agonists did not. Therefore, the opioid receptor present in skeletal muscle fibers of the mouse is of the 6 subtype and the number of these receptors is increased in type II diabetes in the mouse.

Accession: 002590253

PMID: 7784267

DOI: 10.1016/0196-9781(94)00185-5

Download PDF Full Text: Delta-opioid peptide receptors in muscles from obese diabetic and normal mice


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Evans, A.A.L.; Smith, M.E., 1996: Distribution of opioid peptide receptors in muscles of lean and obese-diabetic mice. Autoradiography was used to demonstrate beta-endoiphin and delta-opioid receptors in muscles of normal and obese-diabetic mice. The density of the receptors was significantly higher in the obese-diabetic mice. In both normal and diabetic mice, gly...

Evans, A.A.; Tunnicliffe, G.; Knights, P.; Bailey, C.J.; Smith, M.E., 2001: Delta opioid receptors mediate glucose uptake in skeletal muscles of lean and obese-diabetic (ob/ob) mice. Specific binding sites for [125l] beta -endorphin and the delta < sub>1</ sub>-opioid [3H][D-pen2, D-pen5]enkephalin (DPDPE) were quantified using autoradiography in soleus and extensor digitorum longus (EDL) muscles of lean and obese-...

Evans, A.A.L.; Smith, M.E., 1995: Opioid receptors in fast and slow skeletal muscles of lean and obese-diabetic mice in vitro. Journal of Physiology (Cambridge) 483P(0): 78P-79P

Sánchez-Blázquez, P.; García-Espãna, A.; Garzón, J., 1997: Antisense oligodeoxynucleotides to opioid mu and delta receptors reduced morphine dependence in mice: role of delta-2 opioid receptors. Repeated intracerebroventricular injections of antisense oligodeoxynucleotides (ODNs) were used to selectively restrict the expression of cloned mu and delta opioid receptors (OR) in the mouse brain. Reduction of mu and delta OR-like immunoreactiv...

Zhao, G.M.n; Plotnikoff, N.P.; Bhargava, H.N., 1996: Effects of multiple intracerebroventricular injections of delta-1- or delta-2- opioid receptor agonists on brain delta opioid receptors in mice. Society for Neuroscience Abstracts 22(1-3): 170

Rutherford, J.M.; Wang, J.; Xu, H.; Dersch, C.M.; Partilla, J.S.; Rice, K.C.; Rothman, R.B., 2008: Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors. Based on non-competitive binding interactions we suggested that mu and delta receptors associate as a mu/delta receptor complex in rat brain. We hypothesized that the same non-competitive binding interactions observed in rat brain will be seen in...

Evans, A.A.L.; Smith, M.E., 2004: Opioid receptors in fast and slow skeletal muscles of normal and dystrophic mice. The density of beta-endorphin receptors and the proportions of fibres that expressed the receptors was assessed in fast extensor digitorum longus muscle and slow soleus muscles of normal and dystrophic mice using (125I) beta-endorphin and autoradi...

Kamei, J.; Kawashima, N.; Kasuya, Y., 1992: Paradoxical analgesia produced by naloxone in diabetic mice is attributable to supersensitivity of delta-opioid receptors. The effects of naloxone on the analgesic response were examined using the tail-flick test, in mice with streptozotocin-induced diabetes. Subcutaneous injection of naloxone (5 mg/kg, s.c.) produced a marked analgesia in diabetic mice but not in age...

Kamei, J.; Iwamoto, Y.; Misawa, M.; Nagase, H.; Kasuya, Y., 1994: Antitussive effect of (+/-) pentazocine in diabetic mice is mediated by delta-sites, but not by mu- or kappa-opioid receptors. The effects of streptozotocin-induced diabetes on the antitussive effect of (+/-) pentazocine were examined in mice. Intracerebroventricular (i.c.v.) administration of (+/-) pentazocine produced a dose-dependent antitussive effect in both diabetic...

Xu, H.; Lu, Y.F.; Partilla, J.S.; Pinto, J.; Calderon, S.N.; Matecka, D.; Rice, K.C.; Lai, J.; Porreca, F.; Ananthan, S.; Rothman, R.B., 1998: Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors. Quantitative ligand binding studies resolved two subtypes of the delta opioid receptor, termed delta(ncx1) and delta(ncx2), in mouse brain membranes depleted of mu receptors by pretreatment with the irreversible ligand, BIT. The purpose of the pre...