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Delta-opioid peptide receptors in muscles from obese diabetic and normal mice

, : Delta-opioid peptide receptors in muscles from obese diabetic and normal mice. Peptides (Tarrytown) 16(2): 361-364

Autoradiography was used to study the opioid receptors in soleus and extensor digitorum longus (EDL) muscles from normal mice and mice with type II diabetes. Binding sites for (125I)beta-endorphin were present on the surface membranes in muscles from normal mice. The density of receptors was higher in muscles from obese diabetic mice. The specific delta-opioid ligands DPDPE and (D-Ala-2)deltorphin-II inhibited the binding of (125I)beta-endorphin whereas mu and kappa agonists did not. Therefore, the opioid receptor present in skeletal muscle fibers of the mouse is of the 6 subtype and the number of these receptors is increased in type II diabetes in the mouse.

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Accession: 002590253

PMID: 7784267

DOI: 10.1016/0196-9781(94)00185-5

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