EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Dengue virus premembrane and membrane proteins elicit a protective immune response


, : Dengue virus premembrane and membrane proteins elicit a protective immune response. Virology 185(1): 505-508

We have constructed recombinant vaccinia viruses that express the premembrane (pre-M), membrane (M), or the cleaved, residual portion of pre-M (non-M) protein of dengue 4 virus, or the pre-M, non-M, or envelope (E) proteins of dengue 2 virus, to evalute their ability to induce protective immunity in mice. Cells infected with these recombinants make proteins of expected size. Mice immunized with recombinants expressing dengue 4 pre-M or M were protected against subsequent dengue 4 encephalitis challenge, but non-M was not protective. A recombinant that expressed dengue 2 E was partially protective against homotypic challenge, but dengue 2 pre-M was not protective. However, a recombinant that expressed both pre-M and E as a polyprotein gave solid protection, while the simultaneous administration of the two recombinants expressing pre-M and E gave a significant level of protection. Pre-M and M function as antigens eliciting a protective immune response, and the combination of pre-M plus E is more protective than E alone.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 002590429

PMID: 1926792

DOI: 10.1016/0042-6822(91)90809-p

PDF Full Text: Dengue virus premembrane and membrane proteins elicit a protective immune response


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Pattyn, A.; Morin, X.; Cremer, H.; Goridis, C.; Brunet, J.F., 1997: Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Recent evidence suggests that specific families of homeodomain transcription factors control the generation and survival of distinct neuronal types. We had previously characterized the homeobox gene Phox2a, which is expressed in differentiating ne...

Himukai, R.K.zuhara, T.H.rikoshi, M., 1999: Relationship between the subcellular localization and structure of catalytic domains of FKBP-type PPIases. Journal of biochemistry 126(5): 879-888

Ruckrich, H. U., 1981: Research on the development of Paramphistomum cervi, in the intermediate snail host Planorbis planorbis. Miracidia of P. cervi penetrated the snail within 3 h. At least 25 miracidia were necessary for successful infection. At 25 deg C immature sporocysts were present on the first day and mature stages on the 5th day. Free rediae were found after 11 d...

MATSUDA.N.; KIRIMURA.S., 1963: Precancerous melanosis resulting in malignant melanoma of the conjunctiva. Nihon Ganka Kiyo 14: 67-70

Pihlblad, M.; Chelnis, J.; Schaefer, D., 2015: Eyelid desmoplastic trichilemmoma: 2 case reports and review. Desmoplastic trichilemmomas (DTs) are a rare variant of trichilemmomas first described in 1985. Since then, 11 cases involving the eyelid have been reported. Two cases of this study raise this total to 13. DTs are often clinically confused with ba...

Montenegro, V.; Chiamolera, M.; Launay, P.; Goncalves, C.R.; Monteiro, R.C., 1999: High levels of serum IgA in ankylosing spondylitis is associated to a defective IgA Fc receptor expression in blood phagocytic cells. Arthritis & Rheumatism 42(9 SUPPL ): S377, Sept

Korobov, V.P.; Raev, A.B., 1977: Molecular profile of the aminopherases of rat heart cytostructures induced by toxic doses of thyroxine. The development of thyrotoxin intoxication is attended by a sharply increased activity of aminopherases localized in the nuclei, mitochondria and hyaloplasm. The molecular pattern of the study enzymes undergoes a substantial change and is suppleme...

Malaise M.G.; Hazee Hagelstein M.T.; Reuter A.M.; Vrinds Gevaert Y.; Goldstein G.C.; Franchimont P., 1987: Thymopentin stimulates the acth and b endorphin secretions by pituitary cells in vitro. Goldstein, G , J -F Bach And H Wigzell (Ed ) Ucla (University Of California-Los Angeles) Symposia on Molecular And Cellular Biology New Series, Vol 41 Immune Regulation By Characterized Polypeptides; Steamboat Springs, Colorado, Usa, January 25- February 1, 1986 Xxvi+786p Alan R Liss, Inc : New York, New York, Usa Illus 111-120

LePard, GF., 1985: Donacia vulgaris Zschach (Col.: Chrysomelidae) in Cumbria. Entomologist's Record and Journal of Variation, 975-6: 105

LAZAREV, N.V., 1962: On the process of the metastatic spreading of cancer. Kazanskii Meditsinskii Zhurnal 2: 6-11