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Dengue virus-induced cytokine damages the blood-brain barrier


, : Dengue virus-induced cytokine damages the blood-brain barrier. Proceedings of the Indian National Science Academy Part B Biological Sciences 60(1): 45-51

Dengue type 2 virus (DV) induces production of a cytotoxic cytokine (CF2) by macrophages (M-vphi) of mice. The present study, undertaken to investigate the role of CF2 in the breakdown of the blood-brain barrier shows that inoculation of CF2 resulted in leakage of protein-bound Evans blue dye and 51Cr-labelled erythrocytes into the brain tissue of mice. The leakage increased with time after inoculation, reaching peak at 1 hr and the vascular integrity was restored by the 3rd hr. Pretreatment of mice with ranitidine (histamine H-2 receptor blocker) decreased the CF2-induced permeability by 32% while the decreased with anti-CF2 antiserum was 56%. The findings of the present study, and those described earlier, lend credence to the view that CNS involvement during viral infections of mice can be mediated via cytokines.

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