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Depressed CD4+ T lymphocyte proliferative response and enhanced antibody response to viral antigen in chronic lentivirus-induced arthritis

, : Depressed CD4+ T lymphocyte proliferative response and enhanced antibody response to viral antigen in chronic lentivirus-induced arthritis. Journal of Infectious Diseases 171(2): 328-334

The proliferative response of peripheral blood mononuclear cells (PBMC) stimulated with caprine arthritis-encephalitis virus (CAEV) surface glycoprotein (SU) was depressed 4- to 20-fold in Saanen goats with chronic CAEV-induced arthritis compared with asymptomatic goats. Phytohemagglutinin-stimulated responses were not depressed. Complement depletion of PBMC with anti-CD4 or anti-CD8 monoclonal antibodies identified CD4+ T lymphocytes as the antigen-responsive cells in both high-responder asymptomatic goats and low-responder arthritic goats. Serum antibody titers to CAEV SU were 8- to 32-fold higher in goats with chronic arthritis. Increased anti-CAEV SU titers as early as 3 months after infection predicted the eventual development of clinical arthritis. Thus, CAEV-induced arthritis is associated with chronic B cell activation resulting from dominant type 2 immune responses to viral antigen. The clinical outcome of CAEV infection may be determined by differential activation of type 1 or 2 T lymphocyte phenotypes at or near the time of initial exposure to CAEV.

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Accession: 002590589

PMID: 7844368

DOI: 10.1093/infdis/171.2.328

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Hoeh, WR.; Trdan, RJ., 1985: Freshwater mussels (Pelecypoda: Unionidae) of the major tributaries of the St. Clair River, Michigan. Malacological Review, 181-2: 115-116

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Levy, N. O.; Elad, Y.; Katan, J., 2004: Integration of Trichoderma and soil solarization for disease management. We investigated the effects of solarization and T. harzianum T39 soil treatments, alone or combined, on crop yield and disease suppression, especially when a plant growth medium was reused. Trichoderma was applied after solarization. Reusing the s...

Anonymous, 2013: Identification of proteins specifically interacting with YB-1 mRNA 3a UTR and the effect of hnRNP Q on YB-1 mRNA translation. In this study, proteins specifically interacting with the 3 untranslated region (UTR) of mRNA of the multifunctional Y-box-binding protein 1 (YB-1) were identified. One of these, hnRNP Q, was shown to specifically interact with the regulatory ele...

Hammer Sigmund, 1983: Airbone gravity is here. The achievement of practical and useful airborne gravity exploration for petroleum is a major culmination of more than twenty years of research and development. Commercial surveys have now been conducted for three years. The precision and anomaly...

Bochkarev, A. N.; Bochkareva, L. P., 1989: Characteristics of buckwheat mutants in terms of rate of development processes. Six forms differing in morphology from the mutant collection were compared to Viktoriya, the source variety of many of the mutants, for growth rate, as determined by plant height at various growth stages. The mutants differed among themselves and...

Stary, Herbert C., 1992: Evolution and progression of atherosclerotic lesions in the first forty years of life. (see Book Title) [Author] Gotto, A M Jr , et al (Ed ) Treatment of severe dyslipoproteinemia in the prevention of coronary heart disease; 3rd International Symposium, Munich, Germany, October 17-18, 1990 ix+366p S Karger AG: Basel, Switzerland; New York, New York, USA Illus ISBN 3-8055-5539-3 : 1-8

Iancu T.C.; Shiloh H.; Dembo L., 1986: Hepatomegaly following short term high dose steroid therapy. Children treated with large doses of corticosteroids were found to develop hepatomegaly within a few days. No relationship could be established between the condition for which steroids were given and the liver enlargement. Liver biopsy was thought...

Raeva S.N.; Maslov P.I.; Kokarev A.A., 1973: Device for recording the activity of individual neurons of deep structures of the human brain. Fiziologicheskii Zhurnal SSSR Imeni I M Sechenova 59(11): 1761-1763