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Depressed specific and nonspecific immune responses in secondary Brugia pahangi infection in jirds


, : Depressed specific and nonspecific immune responses in secondary Brugia pahangi infection in jirds. Southeast Asian Journal of Tropical Medicine and Public Health 25(2): 272-277

The immune responsiveness to specific antigens or mitogens was examined in jirds after primary and secondary infections with Brugia pahangi. When spleen cells were obtained from secondarily infected jirds, their proliferative responses to mitogens such as Con A or LPS, or to specific antigens prepared from infective larvae or adult worms were significantly lower than those of spleen cells obtained from primarily infected jirds. The proliferative responses of the peripheral blood mononuclear cells obtained from animals undergoing primary and secondary infections also showed a similar tendency. The depressed proliferative responses of the secondary infected spleen cells to Con A or LPS was partially restored by removing adherent/phagocytic cells from the original cell populations. After deletion of the adherent cells, however, antigen-specific proliferative responses were not altered and remained at low level. These results suggest that at least two different mechanisms of depression, namely adherent cell-mediated antigen-nonspecific suppression and unresponsiveness of lymphocytes to filarial antigens, are induced in jirds in the secondary infection.

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Accession: 002590592

PMID: 7531872

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Related references

Lin, Dah Sheng, 1995: Early immune responses of jirds with Brugia pahangi infection. This study was undertaken to elucidate the cellular and humoral responses induced in jirds during the early stage of Brugia pahangi infection. In vitro response to third-stage larval antigens (Ag) was first evident on day 2 postinfection (PI) by s...

Klei, T.R.; McVay, C.S.; Dennis, V.A.; Coleman, S.U.; Enright, F.M.; Casey, H.W., 1990: Brugia pahangi: effects of duration of infection and parasite burden on lymphatic lesion severity, granulomatous hypersensitivity, and immune responses in jirds (Meriones unguiculatus). The effects of Brugia phagangi infection duration and parasite burden on parasite-associated inflammatory and immune responses were determined over a 181-day period in jirds receiving from one to eight inoculations of infective larvae. Multiple in...

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Kowalski J.; Nielson R., 1982: Immuno electrophoresis of brugia pahangi antigens and serum from brugia pahangi infected jirds. Molecular & Biochemical Parasitology (SUPPL): 655

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