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Desferrioxamine: its effects on the growth of micro-organisms in vitro and in experimental infections


, : Desferrioxamine: its effects on the growth of micro-organisms in vitro and in experimental infections. Reviews in Medical Microbiology 4(3): 171-175

The effects of desferrioxamine on the in vitro growth of bacteria and fungi and upon the course of experimental infections are reviewed. In some microorganisms deferoxamine stimulates growth and enhances virulence, while in others the drug suppresses growth and attenuates the course of experimental infection. The mechanism underlying this difference is based on the microorganisms's ability to utilize iron provided by the deferoxamine-iron complex.

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