Disposition kinetics and bioavailability of long-acting oxytetracycline in afebrile and febrile dog
Maji, A.K.; Mandal, T.K.; Majumder, S.; Juliet, S.; Chakraborty, A.K.
Indian Journal of Animal Sciences 64(5): 455-459
ISSN/ISBN: 0367-8318 Accession: 002595870
A cross-over study was carried out in mongrel dogs to determine the plasma pharmacokinetics of long-acting oxytetracycline following either intravenous or intramuscular route in healthy and experimentally induced febrile dogs. The plasma concentrations of oxytetracycline were lower in febrile than in healthy dogs following both intravenous and intramuscular administration. Oxytetracycline was detected in febrile dogs at 48 and 36 hr following intramuscular and intravenous injections respectively. The pharmacokinetics parameters like t1/2-beta, AUC were lower after intramuscular, and Vd-area, Cl-beta and Kcl were higher after intravenous administration in febrile dogs. The bioavailability was also lower (61%) in febrile dogs than in normal dogs (91%). The dosage regimens were also calculated.