+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Disposition of penicillin G after administration of benzathine penicillin G, or a combination of benzathine penicillin G and procaine penicillin G in cattle



Disposition of penicillin G after administration of benzathine penicillin G, or a combination of benzathine penicillin G and procaine penicillin G in cattle



American Journal of Veterinary Research 55(6): 825-830



Plasma concentration of penicillin G was evaluated in beef steers after administration of either a combination of benzathine penicillin G and procaine penicillin G in a 1:1 mixture at a dosage of 9,000 U/ kg of body weight, im (n = 5), 24,000 U/kg, IM (n = 5), or 8,800 U/kg, SC (n = 5), or benzathine penicillin G alone at a dosage of 12,000 U/kg, IM (n = 7). Plasma concentration of penicillin G was measured by use of a high-performance liquid chromatography assay that had a limit of determination of 0.005 mu-g/ml. At a dosage for this combination of 9,000 U/kg IM, and 8,800 U/kg, SC, which are approved label recommendations in Canada, and the United States, respectively, mean (+- SEM) peak plasma concentration was 0.58 (+- 0.15) and 0.44 (+- 0.02) mu-g/ml, respectively. Although plasma penicillin concentration was quantifiable for 7 days in the steers that received 9,000 U/kg, IM, and for 4 days in the steers that received 8,800 U/kg, SC, the concentration was lt 0.1 mu-g/ml in both groups after the first 12 hours. After administration of the combination at dosage of 24,000 U/kg, im, there was an initial peak plasma concentration at approximately 2 hours; thereafter, plasma concentration decreased slowly, with half-life of 58 hours. Although plasma penicillin G concentration was quantifiable for 12 days at this dosage, concentration was lt 0.1 mu-g/ml after the first 48 hours. After the initial 48 hours, plasma concentration of penicillin was of similar magnitude and decreased at similar rate for the combination at dosage of 24,000 U/ kg and for 12,000 U/kg of berizathine penicillin G alone. Most of the plasma penicillin G concentration in the first 24 hours after administration of a 1:1 combination of benzathine penicillin G and procaine penicillin G is attributable to absorption of procaine penicillin G. After the first 48 hours, most of the plasma drug concentration appeared to be produced by absorption of penicillin G from benzathine penicillin G. Absorption of benzathine penicillin G produces quantifiable plasma penicillin G concentrations for several days, but they are below the level of susceptibility for most bacteria.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 002595889

Download citation: RISBibTeXText

PMID: 7944023


Related references

Oral administration of penicillin; a comparative study of benzathine penicillin, procaine penicillin and potassium penicillin. Acta Pharmacologica et Toxicologica 11(1): 49-54, 1955

Soluble penicillin & relatively insoluble derivatives: sodium penicillin G, procaine penicillin G & benzathine penicillin G; pharmacological & therapeutic considerations. La Semana Medica 110(4): 115-122, 1957

Serum concentration of penicillin in the horse after repeated intramuscular injections of procaine penicillin G alone or in combination with benzathine penicillin and/or phenylbutazone. American Journal of Veterinary Research 45(5): 1003-1007, 1984

Oral Administration of Penicillin. A Comparative Study of Benzathine Penicillin, Procaine Penicillin and Potassium Penieillin. Basic & Clinical Pharmacology & Toxicology 11(1): 49-54, 1955

Depletion of penicillin G residues in tissues and injection sites of yearling beef steers dosed with benzathine penicillin G alone or in combination with procaine penicillin G. Food Additives and Contaminants 11(1): 1-6, 1994

Body fluid concentrations of penicillin following intramuscular injection of single doses of benzathine penicillin G and/or procaine penicillin G. Antibiotic Medicine & Clinical Therapy 6(4): 232-241, 1959

Application of a spectrophotometric method to the determination of potassium penicillin, procaine penicillin and benzathine penicillin in pharmaceutical preparations. Journal of Pharmacy and Pharmacology 10(12): 762-769, 1958

Penicillin blood levels in pigs after subcutaneous injection of procaine penicillin, benzathine penicillin and Penatrit.. Med. Wet 18: 654-658, 1962

Adverse effects associated with inadvertent intravenous penicillin G procaine-penicillin G benzathine administration in two dogs and a cat. Journal of the American Veterinary Medical Association 238(4): 507-510, 2011

Benzathine penicillin G, alone and in combination with procaine penicillin, in outpatient treatment of medically indigent children with acute respiratory infections. Antibiotic Medicine & Clinical Therapy 4(6): 333-342, 1957

Administration of potassium penicillin and benzathine penicillin: comparison of penicillin levels in serum. Harefuah 82(9): 391-393, 1972

A single dose of benzathine penicillin G is as effective as multiple doses of benzathine penicillin G for the treatment of HIV-infected persons with early syphilis. Clinical Infectious Diseases 60(4): 653-660, 2015

Procaine penicillin and interrupted penicillin treatment in Streptococcus agalactiae mastitis I. Procaine penicillin in the bovine udder. II. Therapy studies with procaine penicillin and calcium penicillin. Vet Rec 62(2): 11-14, 1950

Concentration of penicillin in the blood of sheep after injection of crystalline, procaine or benzathine penicillin.. Med. Wet 18: 14-17, 1962

Benzathine penicillin G and procaine penicillin G in piglets: comparison of intramuscular and subcutaneous injection. Veterinary Research Communications 26(6): 459-465, 2002