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Effect of rhynchophylline on potassium channels in isolated rat or guinea pig ventricular myocytes



Effect of rhynchophylline on potassium channels in isolated rat or guinea pig ventricular myocytes



Yaoxue Xuebao 29(1): 9-14



Effects of rhynchophylline (Rhy) on the voltage-dependent potassium channels in isolated rat and guinea pig ventricular myocytes were studied by using patch clamp whole cell recording techniques. Rhy was found to reduce the steady-state outward current in rat ventricular myocytes when cells were depolarized from holding potential -40 mV to 0 mV. After blocking Ca-2+ inward current with CdCl-2 0.1 mmol/L, a K+ transient outward current (I-A) can be recorded. Rhy 30 mu-mol/L inhibited the I-A 30% when depolarized to +50 mV from the holding potential. The delayed outward (I-K) and outward tail current (I-tail) were also reduced 30% and 60%, respectively by Rhy 30 mu-mol/L which responded to 4.5 sec long pulse from -40 mV to -50 mV. Whereas, the inward rectifying current (I-K1) was not changed by Rhy. The present study suggests that the antiarrhythmic action of Rhy was partially due to the K+ channel blocking effects.

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Accession: 002604116

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PMID: 8036902



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