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Effect of sodium selenite on growth, insulin-like growth factor-binding proteins and insulin-like growth factor-I in rats



Effect of sodium selenite on growth, insulin-like growth factor-binding proteins and insulin-like growth factor-I in rats



Journal of Endocrinology 145(1): 105-112



Selenium is an essential trace element although at higher doses it is also known to be a toxic agent causing a wide range of symptoms including growth retardation. In order to investigate the effect of sodium selenite on growth, insulin-like growth factor-binding proteins (IGFBPs) and insulin-like growth factor-I (IGF-I), 30 male Wistar rats were randomized into three groups. Group A was treated with sodium selenite in the drinking water (3.3 mg selenium/l). Group B was ad libitum fed with free access to standard fodder and tap water and group C was pair fed relative to the selenium-treated rats. Serum IGF-I and IGFBPs were determined on days 0, 14 and at the end of the study on day 35. Selenium-treated rats had significantly lower body weights compared with group B rats on day 9 and group C rats on day 14 (P lt 0.05). Tibia length was measured at the end of the study and no difference was observed between groups B and C (3.77 +- 0.04 cm vs 3.60 +- 0.02 cm); however, selenium-treated rats had significantly shorter tibia lengths (3.46 +- 0.03 cm) compared with rats in groups B (P lt 0.001) and C (P lt 0.05). Selenium treatment induced a significant reduction in circulating IGF-I by the end of the study compared with ad libitum and pair fed rats (P lt 0.05). Serum subjected to Western ligand blots showed four distinct IGFBP bands with apparent relative molecular weights of 38-47 kDa (doublet) (IGFBP-3), 30 kDa (IGFBP-1 and/or IGFBP-2) and 24 kDa (IGFBP-4). At the end of the study a significant reduction in IGFBP-3 was observed in group A compared with groups B and C (P lt 0.05). Selenium treatment also caused a reduction in IGFBP-1 and/or IGFBP-2 compared with ad libitum fed rats; in addition, a reduction was observed in pair fed controls. In conclusion, sodium selenite treatment leads to growth retardation accompanied by reduced circulating levels of IGF-I, IGFBP-3, and IGFBP-1 and/or IGFBP-2. The reduction in IGF-I and IGFBP-3 could not be attributed to reduced caloric intake but seems to be a specific action of selenium.

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Accession: 002604529

Download citation: RISBibTeXText

PMID: 7541068

DOI: 10.1677/joe.0.1450105



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