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Effect of streptolysin-S on responsiveness of polymorphonuclear leucocytes

Effect of streptolysin-S on responsiveness of polymorphonuclear leucocytes

Pakistan Veterinary Journal 14(1): 11-14

Most strains of Streptococcus pyogenes (group A, beta-haemolytic) contain a potent leukotoxic factor. When bacteria containing relatively large quantities of this factor are ingested by or come into contact with the neutrophils (PMNs), they are destroyed. Death of PMNs is associated with intracytoplasmic rupture of PMN granules; this release of granule contents is thought to be the leukocidal killing mechanism.

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