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Effects of serotonin antagonist, cyproheptadine, and serotonin depletor, p-chlorophenylalanine, on feeding in rats kept at high and temperate-ambient temperatures



Effects of serotonin antagonist, cyproheptadine, and serotonin depletor, p-chlorophenylalanine, on feeding in rats kept at high and temperate-ambient temperatures



Animal Science & Technology 66(7): 594-598



The present study was conducted to examine the participation of serotonin (5 HT) in the regulation of appetite in rats acclimated to hot (33 degree C) and temperate (26 degree C) environments. The central administration of noradrenaline exerted a stimulative effect on food intake at 26 and 33 degree C. However, the increment of food intake after noradrenaline administration at 33 degree C was less than that at 26 degree C (0.4 vs. 1.0 g), Cyproheptadine, a 5HT antagonist, did not stimulate feeding in rats given noradrenal in eat the two temperatures. Food intake was increased by cyproheptadine alone at 26 degree C, but not at 33 degree C. Thus, serotoninergic activity might not be correlated with the suppression in eating elicited by noradrenaline in the hot environment. In a daytime, there was not a significant difference in food intake between the two temperatures before p-chlorophenylalanine (PCPA), a 5HT depletor, was given. Food intake was significantly (p lt 0.01) increased by PCPA in daytime and nighttime at the two temperatures. However, the food intake at 33 degree C was significantly (p lt 0.01) less than that at 26 degree C. The results of the present study suggest that the activation of serotoninergic neurons may not be the main factor controlling food intake inhibitively in a hot environment.

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Accession: 002609184

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