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High-performance liquid chromatographic method for the enantioselective analysis of mefloquine in plasma and urine



High-performance liquid chromatographic method for the enantioselective analysis of mefloquine in plasma and urine



Journal of Chromatography B Biomedical Applications 655(1): 153-157



An HPLC method for analysis of the enantiomers of the antimalarial drug mefloquine is presented. A complete resolution of (-)-(11S,2'R) and (+)-(11R,2'S) erythro-mefloquine from plasma and urine was obtained on a commercial AGP column. Mefloquine enantiomers were detected by UV at 222 nm. The separation factor (a) at + 20 degree C was 1.50. The limit of determination (coefficient of variation 4.0%) for the enantiomeric ratio (11S,2'R)/ (11R,2'S) is 15:1 at a total mefloquine concentration of 1.6 mM.

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Accession: 002631417

Download citation: RISBibTeXText

PMID: 8061825

DOI: 10.1016/0378-4347(94)00027-1



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