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Inhibitory effect of berberine on potassium channels in guinea pig ventricular myocytes



Inhibitory effect of berberine on potassium channels in guinea pig ventricular myocytes



Yao Xue Xue Bao 29(8): 576-580



The effects of berberine on potassium channel subtypes were investigated by using patch-clamp whole cell recording techniques. Berberine is known to be effective in lowering blood glucose and ameliorating arrhythmia. Our results indicate that, berberine can prolong action potential duration (APD), decrease I-K1 and outward I-tail, but showed no effect on I-K. In addition, berberine was also shown to antagonize cromakalim (BRL-34915) induced inhibition of APD and the increase of K-ATP. These suggest that berberine can inhibit voltage- dependent and ATP- sensitive potassium channels. It appears that the mechanisms of antiarrhythmic and antidiabetic action of berberine might be due to its potassium channel blocking effects.

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Accession: 002641064

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PMID: 7985516



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