+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibitory effect of berberine on potassium channels in guinea pig ventricular myocytes



Inhibitory effect of berberine on potassium channels in guinea pig ventricular myocytes



Yao Xue Xue Bao 29(8): 576-580



The effects of berberine on potassium channel subtypes were investigated by using patch-clamp whole cell recording techniques. Berberine is known to be effective in lowering blood glucose and ameliorating arrhythmia. Our results indicate that, berberine can prolong action potential duration (APD), decrease I-K1 and outward I-tail, but showed no effect on I-K. In addition, berberine was also shown to antagonize cromakalim (BRL-34915) induced inhibition of APD and the increase of K-ATP. These suggest that berberine can inhibit voltage- dependent and ATP- sensitive potassium channels. It appears that the mechanisms of antiarrhythmic and antidiabetic action of berberine might be due to its potassium channel blocking effects.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 002641064

Download citation: RISBibTeXText

PMID: 7985516


Related references

Effects of berberine of L- and T-type calcium channels in guinea pig ventricular myocytes. Zhongguo Yao Li Xue Bao 18(6): 515-518, 1997

Effects of berberine on L- and T-type calcium channels in guinea pig ventricular myocytes. Acta Pharmacologica Sinica 18(6): 515-518, 1997

Effect of rhynchophylline on potassium channels in isolated rat or guinea pig ventricular myocytes. Yaoxue Xuebao 29(1): 9-14, 1994

Effect of angiotensin II on potassium channels of ischemic ventricular myocytes of the guinea pig. Sheng Li Xue Bao 54(2): 149-153, 2002

Effect of phenamil on potassium and calcium channels of guinea pig ventricular myocytes. Journal of Pharmacology & Experimental Therapeutics 274(2): 649-656, 1995

Effect of anoxic preconditioning on ATP-sensitive potassium channels in guinea-pig ventricular myocytes. Pfluegers Archiv European Journal of Physiology 439(6): 808-813, 2000

The effect of levobunolol hydrochloride on the calcium and potassium channels in isolated ventricular myocytes of guinea pig. Journal of Tongji Medical University 17(2): 90-93, 1997

Potassium inhibition of sodium-activated potassium (KNa) channels in guinea-pig ventricular myocytes. Journal of Physiology (Cambridge) 526(1): 81-90, 2000

Inhibitory effect of tocainide on calcium current and potassium current in guinea pig ventricular myocytes. Yao Xue Xue Bao 30(6): 412-416, 1995

Stimulation of current through potassium atp channels of guinea pig ventricular myocytes by extracellular ph. Journal of Molecular & Cellular Cardiology 24(Suppl. 1): S109, 1992

Lactate activates ATP-sensitive potassium channels in guinea pig ventricular myocytes. Journal of Clinical Investigation 88(5): 1772-1777, 1991