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Intraepithelial recruitment and persistence of CD8+ T cells during experimental oral candidiasis in anti-CD4-treated mice



Intraepithelial recruitment and persistence of CD8+ T cells during experimental oral candidiasis in anti-CD4-treated mice



Immunology and Infectious Diseases 4(4): 219-227



An experimental model of oral candidiasis was used in the mouse to test the hypothesis that CD4+ T cells are stimulated by an oral contact with Candida albicans and that they are associated with the resolution of a primary infection. As a corollary it was investigated whether a sustained infection of the oral mucosa and a higher level of Candida in the carrier state would be permitted in anti-CD4-treated mice. This paper reports that the resolution of a primary infection to the carrier state of Candida is similar in control and anti-CD4-treated mice and independent of the expression of delayed-type hypersensitivity. The mucosal immune response to the infectious challenge is different in the two groups of mice, CD8+ T cells being recruited and locally maintained in the epithelium only in the treated mice. In both groups of mice, CD4+ T cells are rapidly recruited in the oral mucosa indicating that in anti-CD4-treated mice, antigenic stimulation also rescues a residual population of CD4+ T cells for migration to infectious foci. However, CD4+ T cells persist in an intraepithelial location in control mice only. It is concluded that both CD4+ and CD8+ intraepithelial T cells may be involved in the maintenance of the oral carrier state of Candida, and that this resistance may be dissociated from the type IV hypersensitivity reaction.

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Accession: 002643300

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