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Kinetics of the inhibition of electric eel and honeybee head acetylcholinesterase by organophosphorus pesticides and n-methylcarbamates, using n-methylindoxyl acetate as the substrate



Kinetics of the inhibition of electric eel and honeybee head acetylcholinesterase by organophosphorus pesticides and n-methylcarbamates, using n-methylindoxyl acetate as the substrate



Toxicological and Environmental Chemistry 42(1/2): 19-34



A previously proposed kinetic theory for irreversible inhibition of acetylcholinesterase (AChE) by insecticides is extended to reaction systems containing a weak substrate. The usefulness of this theory was examined for the system housefly AChE/carbofuran/N-methylindoxyl acetate (MIA) by means of data for an HPLC post-column reaction detector, and for the systems eel AChE/insecticide/MIA and honeybee AChE/insecticide/MIA.

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Accession: 002646326

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